Synovial fibroblasts assume distinct functional identities and secrete R-spondin 2 in osteoarthritis

Alexander J Knights; Easton C Farrell; Olivia M Ellis; Lindsey Lammlin; Lucas M Junginger; Phillip M Rzeczycki; Rachel F Bergman; Rida Pervez; Monique Cruz; Eleanor Knight; Dennis Farmer; Alexa A Samani; Chia-Lung Wu; Kurt D Hankenson; Tristan Maerz

doi:10.1136/ard-2022-222773

Article info

Osteoarthritis

Synovial fibroblasts assume distinct functional identities and secrete R-spondin 2 in osteoarthritis

Authors

Alexander J Knights Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, Michigan, USA PubMed articles Google scholar articles
Easton C Farrell Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, Michigan, USA Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA PubMed articles Google scholar articles
Olivia M Ellis Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, Michigan, USA PubMed articles Google scholar articles
Lindsey Lammlin Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, Michigan, USA PubMed articles Google scholar articles
Lucas M Junginger Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, Michigan, USA PubMed articles Google scholar articles
Phillip M Rzeczycki Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, Michigan, USA PubMed articles Google scholar articles
Rachel F Bergman Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, Michigan, USA PubMed articles Google scholar articles
Rida Pervez Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, Michigan, USA PubMed articles Google scholar articles
Monique Cruz Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, Michigan, USA PubMed articles Google scholar articles
Eleanor Knight Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, Michigan, USA PubMed articles Google scholar articles
Dennis Farmer Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, Michigan, USA PubMed articles Google scholar articles
Alexa A Samani Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, Michigan, USA PubMed articles Google scholar articles
Chia-Lung Wu Department of Orthopaedic Surgery and Rehabilitation, University of Rochester, Rochester, New York, USA PubMed articles Google scholar articles
Kurt D Hankenson Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, Michigan, USA Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA PubMed articles Google scholar articles
Tristan Maerz Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, Michigan, USA Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA PubMed articles Google scholar articles

Correspondence to Dr Tristan Maerz, Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, Michigan, USA; tmaerz{at}med.umich.edu

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Citation

Knights AJ, Farrell EC, Ellis OM, et al

Synovial fibroblasts assume distinct functional identities and secrete R-spondin 2 in osteoarthritis

Annals of the Rheumatic Diseases 2023;82:272-282.

Publication history

Received May 8, 2022
Accepted September 22, 2022
First published September 29, 2022.

Online issue publication

January 23, 2023

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