Targeting FoxO transcription factors with HDAC inhibitors for the treatment of osteoarthritis

Hiroki Ohzono; Yiwen Hu; Keita Nagira; Haruhisa Kanaya; Naoki Okubo; Merissa Olmer; Masafumi Gotoh; Ichiro Kurakazu; Yukio Akasaki; Manabu Kawata; Emily Chen; Alan C Chu; Kristen A Johnson; Martin K Lotz

doi:10.1136/ard-2021-221269

Article info

Osteoarthritis

Targeting FoxO transcription factors with HDAC inhibitors for the treatment of osteoarthritis

Authors

Hiroki Ohzono Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, USA Department of Orthopaedic Surgery, Kurume University Hospital, Kurume, Japan PubMed articles Google scholar articles
Yiwen Hu Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, USA Department of Radiology, Fudan University, Shanghai, China PubMed articles Google scholar articles
Keita Nagira Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, USA Department of Orthopaedic Surgery, Tottori University, Tottori, Japan PubMed articles Google scholar articles
Haruhisa Kanaya Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, USA Department of Orthopaedic Surgery, Tottori University, Tottori, Japan PubMed articles Google scholar articles
Naoki Okubo Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, USA Department of Orthopaedics, Kyoto Prefectural University of Medicine, Kyoto, Japan PubMed articles Google scholar articles
Merissa Olmer The Scripps Research Institute, La Jolla, California, USA PubMed articles Google scholar articles
Masafumi Gotoh Department of Orthopaedic Surgery, Kurume University Hospital, Kurume, Japan PubMed articles Google scholar articles
Ichiro Kurakazu The Scripps Research Institute, La Jolla, California, USA Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Kyushu, Japan PubMed articles Google scholar articles
Yukio Akasaki Department of Orthopaedics, Kyushu University, Kyushu, UK PubMed articles Google scholar articles
Manabu Kawata Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, USA PubMed articles Google scholar articles
Emily Chen Calibr, a Division of Scripps Research Institute, La Jolla, California, USA PubMed articles Google scholar articles
Alan C Chu Calibr, a Division of Scripps Research Institute, La Jolla, California, USA PubMed articles Google scholar articles
Kristen A Johnson Calibr, a Division of Scripps Research Institute, La Jolla, California, USA PubMed articles Google scholar articles
Martin K Lotz Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, USA PubMed articles Google scholar articles

Correspondence to Professor Martin K Lotz, Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California 92037, USA; mlotz{at}scripps.edu

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Citation

Ohzono H, Hu Y, Nagira K, et al

Targeting FoxO transcription factors with HDAC inhibitors for the treatment of osteoarthritis

Annals of the Rheumatic Diseases 2023;82:262-271.

Publication history

Received July 29, 2021
Accepted August 27, 2022
First published September 15, 2022.

Online issue publication

January 23, 2023

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