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Longitudinal analysis of ANA in the Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort
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  • Published on:
    The Impact of Clinical Setting on ANA Responses in SLE: Comment on the article by Choi et al.
    • David S. Pisetsky, Physician Medical Research Service, Durham VA Medical Center, Durham, USA
    • Other Contributors:
      • Peter E. Lipsky, Physician

    The Impact of Clinical Setting on ANA Responses in SLE: Comment on the article by Choi et al.
    David S. Pisetsky1 2 and Peter E. Lipsky3 4
    1 Medical Research Service, Durham VA Medical Center, Durham, North Carolina, USA
    2 Departments of Medicine and Immunology, Duke University Medical Center, Durham, North Carolina, USA
    3 RILITE Foundation, Charlottesville, Virginia, USA
    4 AMPEL BioSolutions LLC, Charlottesville, Virginia, USA

    In a recent paper in the Annals of the Rheumatic Diseases, Choi et al report data on the expression of antinuclear antibodies (ANA) in the sera of patients with systemic lupus erythematosus (SLE).(1) Using a large cohort of well characterized patients from the SLICC (Systemic Lupus International Cooperating Clinics) consortium, the authors show that ANA expression is almost invariable in SLE using three ANA assays (two immunofluorescence or IFA and one ELISA); over time, some changes can occur, with the ELISA showing a greater reduction in the frequency of positive responses than the IFA assays. In this study, patients were early in disease, with the first sample obtained on average 0.58 years after diagnosis.
    Choi et al are to be congratulated for this detailed and comprehensive study that includes longitudinal data. Most other studies on ANA expression in SLE have been cross-sectional in design or involved longitudinal data of relatively few patients.(2) Nevertheless, while consistent with data und...

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    Conflict of Interest:
    None declared.