Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset

Saedis Saevarsdottir; Lilja Stefansdottir; Patrick Sulem; Gudmar Thorleifsson; Egil Ferkingstad; Gudrun Rutsdottir; Bente Glintborg; Helga Westerlind; Gerdur Grondal; Isabella C Loft; Signe Bek Sorensen; Benedicte A Lie; Mikael Brink; Lisbeth Ärlestig; Asgeir Orn Arnthorsson; Eva Baecklund; Karina Banasik; Steffen Bank; Lena I Bjorkman; Torkell Ellingsen; Christian Erikstrup; Oleksandr Frei; Inger Gjertsson; Daniel F Gudbjartsson; Sigurjon A Gudjonsson; Gisli H Halldorsson; Oliver Hendricks; Jan Hillert; Estrid Hogdall; Søren Jacobsen; Dorte Vendelbo Jensen; Helgi Jonsson; Alf Kastbom; Ingrid Kockum; Salome Kristensen; Helga Kristjansdottir; Margit H Larsen; Asta Linauskas; Ellen-Margrethe Hauge; Anne G Loft; Bjorn R Ludviksson; Sigrun H Lund; Thorsteinn Markusson; Gisli Masson; Pall Melsted; Kristjan H S Moore; Heidi Munk; Kaspar R Nielsen; Gudmundur L Norddahl; Asmundur Oddsson; Thorunn A Olafsdottir; Pall I Olason; Tomas Olsson; Sisse Rye Ostrowski; Kim Hørslev-Petersen; Solvi Rognvaldsson; Helga Sanner; Gilad N Silberberg; Hreinn Stefansson; Erik Sørensen; Inge J Sørensen; Carl Turesson; Thomas Bergman; Lars Alfredsson; Tore K Kvien; Søren Brunak; Kristján Steinsson; Vibeke Andersen; Ole A Andreassen; Solbritt Rantapää-Dahlqvist; Merete Lund Hetland; Lars Klareskog; Johan Askling; Leonid Padyukov; Ole BV Pedersen; Unnur Thorsteinsdottir; Ingileif Jonsdottir; Kari Stefansson; Members of the DBDS Genomic Consortium; The Danish RA Genetics Working Group

doi:10.1136/annrheumdis-2021-221754

Article info

Rheumatoid arthritis

Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset

Authors

Saedis Saevarsdottir deCODE genetics/Amgen, Reykjavik, Iceland Division of Clinical Epidemiology, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland Department of Medicine, Landspitali, the National University Hospital of Iceland, Reykjavik, Iceland PubMed articles Google scholar articles
Lilja Stefansdottir deCODE genetics/Amgen, Reykjavik, Iceland PubMed articles Google scholar articles
Patrick Sulem deCODE genetics/Amgen, Reykjavik, Iceland PubMed articles Google scholar articles
Gudmar Thorleifsson deCODE genetics/Amgen, Reykjavik, Iceland PubMed articles Google scholar articles
Egil Ferkingstad deCODE genetics/Amgen, Reykjavik, Iceland PubMed articles Google scholar articles
Gudrun Rutsdottir deCODE genetics/Amgen, Reykjavik, Iceland PubMed articles Google scholar articles
Bente Glintborg The DANBIO registry, the Danish Rheumatologic Biobank and Copenhagen Center for Arthritis Research (COPECARE), Centre for Rheumatology and Spine Diseases, Centre of Head and Orthopaedics, Copenhagen University Hospital - Rigshospitalet, Glostrup, Denmark Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark PubMed articles Google scholar articles
Helga Westerlind Division of Clinical Epidemiology, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden PubMed articles Google scholar articles
Gerdur Grondal Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland Department of Medicine, Landspitali, the National University Hospital of Iceland, Reykjavik, Iceland Center for Rheumatology Research, Landspitali, the National University Hospital of Iceland, Reykjavik, Iceland PubMed articles Google scholar articles
Isabella C Loft Department of Clinical Immunology, Zealand University Hospital, Køge, Denmark PubMed articles Google scholar articles
Signe Bek Sorensen Molecular Diagnostics and Clinical Research Unit, IRS-Center Sonderjylland, University Hospital of Southern Denmark, Aabenraa, Denmark PubMed articles Google scholar articles
Benedicte A Lie Department of Medical Genetics, University of Oslo, Oslo, Norway Oslo University Hospital, Oslo, Norway PubMed articles Google scholar articles
Mikael Brink Department of Public Health and Clinical Medicine, Rheumatology, Umeå University, Umeå, Sweden PubMed articles Google scholar articles
Lisbeth Ärlestig Department of Public Health and Clinical Medicine, Rheumatology, Umeå University, Umeå, Sweden PubMed articles Google scholar articles
Asgeir Orn Arnthorsson deCODE genetics/Amgen, Reykjavik, Iceland PubMed articles Google scholar articles
Eva Baecklund Department of Medical Sciences, Section of Rheumatology, Uppsala University, Uppsala, Sweden PubMed articles Google scholar articles
Karina Banasik Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark PubMed articles Google scholar articles
Steffen Bank Molecular Diagnostics and Clinical Research Unit, IRS-Center Sonderjylland, University Hospital of Southern Denmark, Aabenraa, Denmark PubMed articles Google scholar articles
Lena I Bjorkman Department of Rheumatology and Inflammation research, University of Gothenburg, Gothenburg, Sweden PubMed articles Google scholar articles
Torkell Ellingsen OPEN Explorative Network, University of Southern Denmark, Odense, Denmark Rheumatology Research Unit, Odense University Hospital and University of Southern Denmark, Odense, Denmark PubMed articles Google scholar articles
Christian Erikstrup Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark PubMed articles Google scholar articles
Oleksandr Frei NORMENT Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway Center for Bioinformatics, Department of Informatics, University of Oslo, Oslo, Norway PubMed articles Google scholar articles
Inger Gjertsson Department of Rheumatology and Inflammation Research, Gothenburg University, Gothenburg, Sweden PubMed articles Google scholar articles
Daniel F Gudbjartsson deCODE genetics/Amgen, Reykjavik, Iceland School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland PubMed articles Google scholar articles
Sigurjon A Gudjonsson deCODE genetics/Amgen, Reykjavik, Iceland PubMed articles Google scholar articles
Gisli H Halldorsson deCODE genetics/Amgen, Reykjavik, Iceland School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland PubMed articles Google scholar articles
Oliver Hendricks Danish Hospital for Rheumatic Diseases, University Hospital of Southern Denmark, Sønderborg, Denmark Department of Regional Health Research, University of Southern Denmark, Odense, Denmark PubMed articles Google scholar articles
Jan Hillert Department of Clinical Neurosciences, Karolinska Institutet, Stockholm, Sweden PubMed articles Google scholar articles
Estrid Hogdall Department of Pathology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark PubMed articles Google scholar articles
Søren Jacobsen Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark Copenhagen Lupus and Vasculitis Clinic, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark PubMed articles Google scholar articles
Dorte Vendelbo Jensen Department of Rheumatology, Center for Rheumatology and Spine Diseases, Gentofte and Herlev Hospital, Rønne, Denmark PubMed articles Google scholar articles
Helgi Jonsson Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland Department of Medicine, Landspitali, the National University Hospital of Iceland, Reykjavik, Iceland PubMed articles Google scholar articles
Alf Kastbom Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden PubMed articles Google scholar articles
Ingrid Kockum Department of Clinical Neurosciences, Karolinska Institutet, Stockholm, Sweden PubMed articles Google scholar articles
Salome Kristensen Department of Rheumatology, Aalborg University Hospital, Aalborg, Denmark Department of Clinical Medicine, Aalborg University, Aalborg, Denmark PubMed articles Google scholar articles
Helga Kristjansdottir Center for Rheumatology Research, Landspitali, the National University Hospital of Iceland, Reykjavik, Iceland PubMed articles Google scholar articles
Margit H Larsen Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark PubMed articles Google scholar articles
Asta Linauskas Department of Clinical Medicine, Aalborg University, Aalborg, Denmark Department of Rheumatology, North Denmark Regional Hospital, Hjørring, Denmark PubMed articles Google scholar articles
Ellen-Margrethe Hauge Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark Department of Clinical Medicine, Aarhus University, Aarhus, Denmark PubMed articles Google scholar articles
Anne G Loft Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark Department of Clinical Medicine, Aarhus University, Aarhus, Denmark PubMed articles Google scholar articles
Bjorn R Ludviksson Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland Department of Immunology, Landspitali, the National University Hospital of Iceland, Reykjavik, Iceland PubMed articles Google scholar articles
Sigrun H Lund deCODE genetics/Amgen, Reykjavik, Iceland PubMed articles Google scholar articles
Thorsteinn Markusson deCODE genetics/Amgen, Reykjavik, Iceland Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland PubMed articles Google scholar articles
Gisli Masson deCODE genetics/Amgen, Reykjavik, Iceland PubMed articles Google scholar articles
Pall Melsted deCODE genetics/Amgen, Reykjavik, Iceland School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland PubMed articles Google scholar articles
Kristjan H S Moore deCODE genetics/Amgen, Reykjavik, Iceland PubMed articles Google scholar articles
Heidi Munk OPEN Explorative Network, University of Southern Denmark, Odense, Denmark Rheumatology Research Unit, Odense University Hospital and University of Southern Denmark, Odense, Denmark PubMed articles Google scholar articles
Kaspar R Nielsen Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark PubMed articles Google scholar articles
Gudmundur L Norddahl deCODE genetics/Amgen, Reykjavik, Iceland PubMed articles Google scholar articles
Asmundur Oddsson deCODE genetics/Amgen, Reykjavik, Iceland PubMed articles Google scholar articles
Thorunn A Olafsdottir deCODE genetics/Amgen, Reykjavik, Iceland Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland PubMed articles Google scholar articles
Pall I Olason deCODE genetics/Amgen, Reykjavik, Iceland PubMed articles Google scholar articles
Tomas Olsson Department of Clinical Neurosciences, Karolinska Institutet, Stockholm, Sweden PubMed articles Google scholar articles
Sisse Rye Ostrowski Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark PubMed articles Google scholar articles
Kim Hørslev-Petersen Danish Hospital for Rheumatic Diseases, University Hospital of Southern Denmark, Sønderborg, Denmark PubMed articles Google scholar articles
Solvi Rognvaldsson deCODE genetics/Amgen, Reykjavik, Iceland PubMed articles Google scholar articles
Helga Sanner Section of Rheumatology, Oslo University Hospital, Oslo, Norway Oslo New University College, Oslo, Norway PubMed articles Google scholar articles
Gilad N Silberberg Division of Rheumatology, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden PubMed articles Google scholar articles
Hreinn Stefansson deCODE genetics/Amgen, Reykjavik, Iceland PubMed articles Google scholar articles
Erik Sørensen Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark PubMed articles Google scholar articles
Inge J Sørensen Copenhagen Lupus and Vasculitis Clinic, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark PubMed articles Google scholar articles
Carl Turesson Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden PubMed articles Google scholar articles
Thomas Bergman Division of Clinical Epidemiology, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden PubMed articles Google scholar articles
Lars Alfredsson Department of Clinical Neurosciences, Karolinska Institutet, Stockholm, Sweden Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden PubMed articles Google scholar articles
Tore K Kvien University of Oslo, Oslo, Norway Diakonhjemmet Hospital, Oslo, Norway PubMed articles Google scholar articles
Søren Brunak Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark PubMed articles Google scholar articles
Kristján Steinsson Center for Rheumatology Research, Landspitali, the National University Hospital of Iceland, Reykjavik, Iceland PubMed articles Google scholar articles
Vibeke Andersen Molecular Diagnostics and Clinical Research Unit, IRS-Center Sonderjylland, University Hospital of Southern Denmark, Aabenraa, Denmark OPEN Explorative Network, University of Southern Denmark, Odense, Denmark Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark PubMed articles Google scholar articles
Ole A Andreassen NORMENT Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway PubMed articles Google scholar articles
Solbritt Rantapää-Dahlqvist Department of Public Health and Clinical Medicine, Rheumatology, Umeå University, Umeå, Sweden PubMed articles Google scholar articles
Merete Lund Hetland The DANBIO registry, the Danish Rheumatologic Biobank and Copenhagen Center for Arthritis Research (COPECARE), Centre for Rheumatology and Spine Diseases, Centre of Head and Orthopaedics, Copenhagen University Hospital - Rigshospitalet, Glostrup, Denmark Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark PubMed articles Google scholar articles
Lars Klareskog Division of Rheumatology, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden PubMed articles Google scholar articles
Johan Askling Division of Clinical Epidemiology, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden PubMed articles Google scholar articles
Leonid Padyukov Division of Rheumatology, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden PubMed articles Google scholar articles
Ole BV Pedersen Department of Clinical Immunology, Zealand University Hospital, Køge, Denmark PubMed articles Google scholar articles
Unnur Thorsteinsdottir deCODE genetics/Amgen, Reykjavik, Iceland Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland PubMed articles Google scholar articles
Ingileif Jonsdottir deCODE genetics/Amgen, Reykjavik, Iceland Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland Department of Immunology, Landspitali, the National University Hospital of Iceland, Reykjavik, Iceland PubMed articles Google scholar articles
Kari Stefansson deCODE genetics/Amgen, Reykjavik, Iceland Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland PubMed articles Google scholar articles
Members of the DBDS Genomic Consortium
Google scholar articles
The Danish RA Genetics Working Group
Google scholar articles
The Swedish Rheumatology Quality Register Biobank Study Group (SRQb)
Google scholar articles

Correspondence to Professor Saedis Saevarsdottir, deCODE Genetics/Amgen, Reykjavik, Iceland; saedis.saevarsdottir{at}decode.is; Professor Kari Stefansson, deCODE genetics/Amgen, Reykjavik, Iceland; kstefans{at}decode.is

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Citation

Saevarsdottir S, Stefansdottir L, Sulem P The Swedish Rheumatology Quality Register Biobank Study Group (SRQb), et al

Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset

Annals of the Rheumatic Diseases 2022;81:1085-1095.

Publication history

Received October 26, 2021
Accepted April 4, 2022
First published April 25, 2022.

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July 12, 2022

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.

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