Immune cell multiomics analysis reveals contribution of oxidative phosphorylation to B-cell functions and organ damage of lupus

Yusuke Takeshima; Yukiko Iwasaki; Masahiro Nakano; Yuta Narushima; Mineto Ota; Yasuo Nagafuchi; Shuji Sumitomo; Tomohisa Okamura; Keith Elkon; Kazuyoshi Ishigaki; Akari Suzuki; Yuta Kochi; Kazuhiko Yamamoto; Keishi Fujio

doi:10.1136/annrheumdis-2021-221464

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Systemic lupus erythematosus

Immune cell multiomics analysis reveals contribution of oxidative phosphorylation to B-cell functions and organ damage of lupus

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Yusuke Takeshima Department of Allergy and Rheumatology, The University of Tokyo, Tokyo, Japan Department of Functional Genomics and Immunological Diseases, The University of Tokyo, Tokyo, Japan PubMed articles Google scholar articles
Yukiko Iwasaki Department of Allergy and Rheumatology, The University of Tokyo, Tokyo, Japan Department of Palliative Medicine, Saitama Medical University, Saitama, Japan PubMed articles Google scholar articles
Masahiro Nakano Department of Allergy and Rheumatology, The University of Tokyo, Tokyo, Japan PubMed articles Google scholar articles
Yuta Narushima Research Division, Chugai Pharmaceutical Co Ltd, Kamakura, Japan PubMed articles Google scholar articles
Mineto Ota Department of Allergy and Rheumatology, The University of Tokyo, Tokyo, Japan Department of Functional Genomics and Immunological Diseases, The University of Tokyo, Tokyo, Japan PubMed articles Google scholar articles
Yasuo Nagafuchi Department of Allergy and Rheumatology, The University of Tokyo, Tokyo, Japan Department of Functional Genomics and Immunological Diseases, The University of Tokyo, Tokyo, Japan PubMed articles Google scholar articles
Shuji Sumitomo Department of Allergy and Rheumatology, The University of Tokyo, Tokyo, Japan PubMed articles Google scholar articles
Tomohisa Okamura Department of Allergy and Rheumatology, The University of Tokyo, Tokyo, Japan Department of Functional Genomics and Immunological Diseases, The University of Tokyo, Tokyo, Japan PubMed articles Google scholar articles
Keith Elkon Division of Rheumatology, University of Washington, Seattle, Washington, USA PubMed articles Google scholar articles
Kazuyoshi Ishigaki Laboratory for Autoimmune Diseases, Center for Integrative Medical Sciences, Riken Yokohama Institute, Yokohama, Japan PubMed articles Google scholar articles
Akari Suzuki Laboratory for Autoimmune Diseases, Center for Integrative Medical Sciences, Riken Yokohama Institute, Yokohama, Japan PubMed articles Google scholar articles
Yuta Kochi Laboratory for Autoimmune Diseases, Center for Integrative Medical Sciences, Riken Yokohama Institute, Yokohama, Japan Department of Genomic Function and Diversity, Tokyo Medical and Dental University, Tokyo, Japan PubMed articles Google scholar articles
Kazuhiko Yamamoto Laboratory for Autoimmune Diseases, Center for Integrative Medical Sciences, Riken Yokohama Institute, Yokohama, Japan PubMed articles Google scholar articles
Keishi Fujio Department of Allergy and Rheumatology, The University of Tokyo, Tokyo, Japan PubMed articles Google scholar articles

Correspondence to Dr Keishi Fujio, Department of Allergy and Rheumatology, The University of Tokyo, Bunkyo-ku, Tokyo, Japan; fujiok-int{at}h.u-tokyo.ac.jp; Dr Yukiko Iwasaki, Department of Palliative Medicine, Saitama Medical University, Saitama, Japan; yu_nyan{at}saitama-med.ac.jp

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Citation

Takeshima Y, Iwasaki Y, Nakano M, et al

Immune cell multiomics analysis reveals contribution of oxidative phosphorylation to B-cell functions and organ damage of lupus

Annals of the Rheumatic Diseases 2022;81:845-853.

Publication history

Received September 6, 2021
Accepted February 9, 2022
First published March 2, 2022.

Online issue publication

October 18, 2023

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