Severe delayed hypersensitivity reactions to IL-1 and IL-6 inhibitors link to common HLA-DRB1*15 alleles

Vivian E Saper; Michael J Ombrello; Adriana H Tremoulet; Gonzalo Montero-Martin; Sampath Prahalad; Scott Canna; Chisato Shimizu; Gail Deutsch; Serena Y Tan; Elaine F Remmers; Dimitri Monos; Timothy Hahn; Omkar K Phadke; Elaine Cassidy; Ian Ferguson; Vamsee Mallajosyula; Jianpeng Xu; Jaime S Rosa Duque; Gilbert T Chua; Debopam Ghosh; Ann Marie Szymanski; Danielle Rubin; Jane C Burns; Lu Tian; Marcelo A Fernandez-Vina; Elizabeth D Mellins; Jill A Hollenbach; Drug Hypersensitivity Consortium

doi:10.1136/annrheumdis-2021-220578

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Severe delayed hypersensitivity reactions to IL-1 and IL-6 inhibitors link to common HLA-DRB1*15 alleles

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Vivian E Saper Pediatrics, Stanford University, Stanford, California, USA PubMed articles Google scholar articles
Michael J Ombrello Translational Genetics and Genomics Unit, NIAMS, National Institutes of Health, Bethesda, Maryland, USA PubMed articles Google scholar articles
Adriana H Tremoulet Pediatrics, University of California San Diego, La Jolla, California, USA PubMed articles Google scholar articles
Gonzalo Montero-Martin Stanford Blood Center, Histocompatibility and Immunogenetics Laboratory, Stanford University, Stanford, California, USA PubMed articles Google scholar articles
Sampath Prahalad Children’s Healthcare of Atlanta, Atlanta, Georgia, USA Pediatrics, Emory University, Atlanta, Georgia, USA PubMed articles Google scholar articles
Scott Canna Pediatrics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA PubMed articles Google scholar articles
Chisato Shimizu Pediatrics, University of California San Diego, La Jolla, California, USA PubMed articles Google scholar articles
Gail Deutsch Pathology, Seattle Children's Hospital, Seattle, Washington, USA PubMed articles Google scholar articles
Serena Y Tan Pathology, Stanford University, Stanford, California, USA PubMed articles Google scholar articles
Elaine F Remmers National Human Genome Research Institute, Bethesda, Maryland, USA PubMed articles Google scholar articles
Dimitri Monos Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA PubMed articles Google scholar articles
Timothy Hahn Pediatrics, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA PubMed articles Google scholar articles
Omkar K Phadke Pediatrics, Emory University, Atlanta, Georgia, USA PubMed articles Google scholar articles
Elaine Cassidy Pediatrics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA PubMed articles Google scholar articles
Ian Ferguson Pediatrics, Yale University School of Medicine, New Haven, Connecticut, USA PubMed articles Google scholar articles
Vamsee Mallajosyula Microbiology and Immunology, Stanford University, Stanford, California, USA PubMed articles Google scholar articles
Jianpeng Xu Pediatrics, Stanford University, Stanford, California, USA PubMed articles Google scholar articles
Jaime S Rosa Duque Pediatrics, University of Hong Kong, Hong Kong Special Adminstrative District, China PubMed articles Google scholar articles
Gilbert T Chua Pediatrics, University of Hong Kong, Hong Kong Special Adminstrative District, China PubMed articles Google scholar articles
Debopam Ghosh Pediatrics, Stanford University, Stanford, California, USA PubMed articles Google scholar articles
Ann Marie Szymanski Translational Genetics and Genomics Unit, NIAMS, National Institutes of Health, Bethesda, Maryland, USA PubMed articles Google scholar articles
Danielle Rubin Translational Genetics and Genomics Unit, NIAMS, National Institutes of Health, Bethesda, Maryland, USA PubMed articles Google scholar articles
Jane C Burns Pediatrics, University of California San Diego, La Jolla, California, USA PubMed articles Google scholar articles
Lu Tian Biomedical Data Science, Stanford University, Stanford, California, USA PubMed articles Google scholar articles
Marcelo A Fernandez-Vina Stanford Blood Center, Histocompatibility and Immunogenetics Laboratory, Stanford University, Stanford, California, USA PubMed articles Google scholar articles
Elizabeth D Mellins Pediatrics, Stanford University, Stanford, California, USA PubMed articles Google scholar articles
Jill A Hollenbach Neurology, University of California San Francisco, San Francisco, California, USA PubMed articles Google scholar articles
Drug Hypersensitivity Consortium
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INCHARGE Consortium
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Correspondence to Dr Vivian E Saper, Pediatrics, Stanford University, Stanford, California, USA; vesaper{at}stanford.edu; Dr Elizabeth D Mellins, Pediatrics, Stanford University, Stanford, California, USA; mellins{at}stanford.edu

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Saper VE, Ombrello MJ, Tremoulet AH INCHARGE Consortium, et al

Severe delayed hypersensitivity reactions to IL-1 and IL-6 inhibitors link to common HLA-DRB1*15 alleles

Annals of the Rheumatic Diseases 2022;81:406-415.

Publication history

Received April 27, 2021
Accepted September 29, 2021
First published November 17, 2021.

Online issue publication

May 04, 2023

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