Antifibrotic factor KLF4 is repressed by the miR-10/TFAP2A/TBX5 axis in dermal fibroblasts: insights from twins discordant for systemic sclerosis

Maya Malaab; Ludivine Renaud; Naoko Takamura; Kip D Zimmerman; Willian A da Silveira; Paula S Ramos; Sandra Haddad; Marc Peters-Golden; Loka R Penke; Bethany Wolf; Gary Hardiman; Carl D Langefeld; Thomas A Medsger; Carol A Feghali-Bostwick

doi:10.1136/annrheumdis-2021-221050

Article info

Systemic sclerosis

Antifibrotic factor KLF4 is repressed by the miR-10/TFAP2A/TBX5 axis in dermal fibroblasts: insights from twins discordant for systemic sclerosis

Authors

Maya Malaab Medicine, Medical University of South Carolina, Charleston, South Carolina, USA PubMed articles Google scholar articles
Ludivine Renaud Medicine, Medical University of South Carolina, Charleston, South Carolina, USA PubMed articles Google scholar articles
Naoko Takamura Medicine, Medical University of South Carolina, Charleston, South Carolina, USA PubMed articles Google scholar articles
Kip D Zimmerman Biostatistical Sciences and Center for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA PubMed articles Google scholar articles
Willian A da Silveira School of Biological Sciences, Institute for Global Food Security, Queen's University Belfast, Belfast, UK PubMed articles Google scholar articles
Paula S Ramos Medicine, Medical University of South Carolina, Charleston, South Carolina, USAPublic Health Sciences, Medical University of South Carolina, Charleston, South Carolina, USA PubMed articles Google scholar articles
Sandra Haddad Science, Bay Path University, Longmeadow, Massachusetts, USA PubMed articles Google scholar articles
Marc Peters-Golden Internal Medicine, University of Michigan Michigan Medicine, Ann Arbor, Michigan, USA PubMed articles Google scholar articles
Loka R Penke Internal Medicine, University of Michigan Michigan Medicine, Ann Arbor, Michigan, USA PubMed articles Google scholar articles
Bethany Wolf Public Health Sciences, Medical University of South Carolina, Charleston, South Carolina, USA PubMed articles Google scholar articles
Gary Hardiman School of Biological Sciences, Institute for Global Food Security, Queen's University Belfast, Belfast, UK PubMed articles Google scholar articles
Carl D Langefeld Biostatistical Sciences and Center for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA PubMed articles Google scholar articles
Thomas A Medsger Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA PubMed articles Google scholar articles
Carol A Feghali-Bostwick Medicine, Medical University of South Carolina, Charleston, South Carolina, USA PubMed articles Google scholar articles

Correspondence to Dr Carol A Feghali-Bostwick, Medicine, Medical University of South Carolina, Charleston, South Carolina, USA; feghalib{at}musc.edu

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Citation

Malaab M, Renaud L, Takamura N, et al

Antifibrotic factor KLF4 is repressed by the miR-10/TFAP2A/TBX5 axis in dermal fibroblasts: insights from twins discordant for systemic sclerosis

Annals of the Rheumatic Diseases 2022;81:268-277.

Publication history

Received June 22, 2021
Accepted September 29, 2021
First published November 8, 2021.

Online issue publication

July 13, 2022

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