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Handling editor Josef S Smolen
Contributors KLH is the sole author of this commentary.
Funding KLH is supported by the NIHR Manchester Biomedical Research Centre.
Competing interests KLH has received honoraria from Abbvie and Grant income from Pfizer and BMS.
Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.
Provenance and peer review Commissioned; externally peer reviewed.