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Mild COVID-19 in ANCA-associated vasculitis treated with rituximab
  1. Silvia Suárez-Díaz1,
  2. Claudia Morán-Castaño1,
  3. Rubén Coto-Hernández2,
  4. Lourdes Mozo-Avellaneda3,
  5. Carlos Suárez-Cuervo1,
  6. Luis Caminal-Montero2
  1. 1 Department of Internal Medicine, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain
  2. 2 Systemic Autoinmune Disease Unit, Department of Internal Medicine, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain
  3. 3 Autoinmunity Section, Inmunology Department, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain
  1. Correspondence to Dr Silvia Suárez-Díaz, Department of Internal Medicine, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain; silvia_porto{at}

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Treatment for antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis usually raises questions about the risk of infections. Particular attention has been given to the impact of drugs such as cyclophosphamide and B-cell depletory therapies on the severity of COVID-19. Monti et al 1 suggest that receiving biological disease-modifying antirheumatic drugs may not increase risk of COVID-19. Furthermore, Guilpain et al 2 reported a woman treated with rituximab and low-dose prednisone due to granulomatosis with polyangeitis proteinase 3- anti-neutrophil cytoplasmic antibody (PR3-ANCA) vasculitis, who developed pneumonia associated with COVID-19 with a milder evolution than expected in other series.

Here, we present a 64-year-old woman diagnosed of myeloperoxidase-ANCA microscopic polyangiitis in 2014, with secondary hypertrophic pachymeningitis, sinusitis and constitutional syndrome. Her main comorbidities were hypercholesterolaemia and areata alopecia. On 25 November 2019, vasculitis relapsed and was treated with two infusions of 1000 mg rituximab given 2 weeks …

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  • Contributors SS-D: writing the paper; CM-C: writing the paper; RC-H: clinical support; CS-C: language supervision; LM-A: immunological diagnosis; LC-M: patient’s primary physician and and head of the autoimmune diseases unit.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.

  • Provenance and peer review Not commissioned; internally peer reviewed.