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Systemic lupus erythematosus
Meta-analysis of 208370 East Asians identifies 113 susceptibility loci for systemic lupus erythematosus

Authors

  • Xianyong Yin Department of Dermatology, First Affiliated Hospital, Anhui Medical University, Hefei, Anhui, China Institute of Dermatology, Anhui Medical University, Hefei, Anhui, China Key Lab of Dermatology, Ministry of Education (Anhui Medical University), Hefei, Anhui, China Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, Anhui, China Department of Dermatology, China-Japan Friendship Hospital, Beijing, China Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA PubMed articlesGoogle scholar articles
  • Kwangwoo Kim Department of Biology and Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul, Korea PubMed articlesGoogle scholar articles
  • Hiroyuki Suetsugu Laboratory for Bone and Joint Diseases, RIKEN Center for Medical Sciences, Kanagawa, Japan Laboratory for Statistical and Translational Genetics Analysis, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan PubMed articlesGoogle scholar articles
  • So-Young Bang Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea Hanyang University Institute for Rheumatology Research, Seoul, Korea PubMed articlesGoogle scholar articles
  • Leilei Wen Department of Dermatology, First Affiliated Hospital, Anhui Medical University, Hefei, Anhui, China Institute of Dermatology, Anhui Medical University, Hefei, Anhui, China Key Lab of Dermatology, Ministry of Education (Anhui Medical University), Hefei, Anhui, China PubMed articlesGoogle scholar articles
  • Masaru Koido Laboratory for Statistical and Translational Genetics Analysis, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan Division of Molecular Pathology, Department of Cancer Biology, Institute of Medical Science, The University of Tokyo, Tokyo, Japan PubMed articlesGoogle scholar articles
  • Eunji Ha Department of Biology and Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul, Korea PubMed articlesGoogle scholar articles
  • Lu Liu Department of Dermatology, First Affiliated Hospital, Anhui Medical University, Hefei, Anhui, China Institute of Dermatology, Anhui Medical University, Hefei, Anhui, China Key Lab of Dermatology, Ministry of Education (Anhui Medical University), Hefei, Anhui, China PubMed articlesGoogle scholar articles
  • Yuma Sakamoto Koga Hospital 21, Fukuoka, Japan PubMed articlesGoogle scholar articles
  • Sungsin Jo Hanyang University Institute for Rheumatology Research, Seoul, Korea PubMed articlesGoogle scholar articles
  • Rui-Xue Leng Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China PubMed articlesGoogle scholar articles
  • Nao Otomo Laboratory for Bone and Joint Diseases, RIKEN Center for Medical Sciences, Kanagawa, Japan Laboratory for Statistical and Translational Genetics Analysis, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan Department of Orthopedic Surgery, Keio University School of Medicine, Tokyo, Japan PubMed articlesGoogle scholar articles
  • Viktoryia Laurynenka Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA PubMed articlesGoogle scholar articles
  • Young-Chang Kwon Hanyang University Institute for Rheumatology Research, Seoul, Korea PubMed articlesGoogle scholar articles
  • Yujun Sheng Department of Dermatology, First Affiliated Hospital, Anhui Medical University, Hefei, Anhui, China Institute of Dermatology, Anhui Medical University, Hefei, Anhui, China Key Lab of Dermatology, Ministry of Education (Anhui Medical University), Hefei, Anhui, China PubMed articlesGoogle scholar articles
  • Nobuhiko Sugano Department of Orthopaedic Medical Engineering, Osaka University Graduate School of Medicine, Osaka, Japan PubMed articlesGoogle scholar articles
  • Mi Yeong Hwang Division of Genome Research, Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Cheongju, Korea PubMed articlesGoogle scholar articles
  • Weiran Li Department of Dermatology, First Affiliated Hospital, Anhui Medical University, Hefei, Anhui, China Institute of Dermatology, Anhui Medical University, Hefei, Anhui, China Key Lab of Dermatology, Ministry of Education (Anhui Medical University), Hefei, Anhui, China PubMed articlesGoogle scholar articles
  • Masaya Mukai Department of Rheumatology & Clinical Immunology, Sapporo City General Hospital, Hokkaido, Japan PubMed articlesGoogle scholar articles
  • Kyungheon Yoon Division of Genome Research, Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Cheongju, Korea PubMed articlesGoogle scholar articles
  • Minglong Cai Department of Dermatology, First Affiliated Hospital, Anhui Medical University, Hefei, Anhui, China Institute of Dermatology, Anhui Medical University, Hefei, Anhui, China Key Lab of Dermatology, Ministry of Education (Anhui Medical University), Hefei, Anhui, China PubMed articlesGoogle scholar articles
  • Kazuyoshi Ishigaki Laboratory for Statistical and Translational Genetics Analysis, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan Divisions of Genetics and Rheumatology, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA Center for Data Sciences, Harvard Medical School, Boston, Massachusetts, USA Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Won Tae Chung Department of Internal Medicine, Dong-A University Hospital, Busan, Korea PubMed articlesGoogle scholar articles
  • He Huang Department of Dermatology, First Affiliated Hospital, Anhui Medical University, Hefei, Anhui, China Institute of Dermatology, Anhui Medical University, Hefei, Anhui, China Key Lab of Dermatology, Ministry of Education (Anhui Medical University), Hefei, Anhui, China PubMed articlesGoogle scholar articles
  • Daisuke Takahashi Department of Orthopaedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Hokkaido, Japan PubMed articlesGoogle scholar articles
  • Shin-Seok Lee Division of Rheumatology, Department of Internal Medicine, Chonnam National University Medical School and Hospital, Gwangju, Korea PubMed articlesGoogle scholar articles
  • Mengwei Wang Department of Dermatology, First Affiliated Hospital, Anhui Medical University, Hefei, Anhui, China Institute of Dermatology, Anhui Medical University, Hefei, Anhui, China Key Lab of Dermatology, Ministry of Education (Anhui Medical University), Hefei, Anhui, China PubMed articlesGoogle scholar articles
  • Kohei Karino Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Hokkaido, Japan PubMed articlesGoogle scholar articles
  • Seung-Cheol Shim Division of Rheumatology, Department of Internal Medicine, Chungnam National University Hospital, Daejeon, Korea PubMed articlesGoogle scholar articles
  • Xiaodong Zheng Department of Dermatology, First Affiliated Hospital, Anhui Medical University, Hefei, Anhui, China Institute of Dermatology, Anhui Medical University, Hefei, Anhui, China Key Lab of Dermatology, Ministry of Education (Anhui Medical University), Hefei, Anhui, China PubMed articlesGoogle scholar articles
  • Tomoya Miyamura Department of Internal Medicine and Rheumatology, National Hospital Organization, Kyushu Medical Center, Fukuoka, Japan PubMed articlesGoogle scholar articles
  • Young Mo Kang Division of Rheumatology, Department of Internal medicine, Kyungpook National University Hospital, Daegu, Korea PubMed articlesGoogle scholar articles
  • Dongqing Ye Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China PubMed articlesGoogle scholar articles
  • Junichi Nakamura Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan PubMed articlesGoogle scholar articles
  • Chang-Hee Suh Department of Rheumatology, Ajou University School of Medicine, Suwon, Korea PubMed articlesGoogle scholar articles
  • Yuanjia Tang Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University, School of Medicine (SJTUSM), Shanghai, China PubMed articlesGoogle scholar articles
  • Goro Motomura Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan PubMed articlesGoogle scholar articles
  • Yong-Beom Park Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea PubMed articlesGoogle scholar articles
  • Huihua Ding Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University, School of Medicine (SJTUSM), Shanghai, China PubMed articlesGoogle scholar articles
  • Takeshi Kuroda Niigata University Health Administration Center, Niigata, Japan PubMed articlesGoogle scholar articles
  • Jung-Yoon Choe Department of Rheumatology, Catholic University of Daegu School of Medicine, Daegu, Korea PubMed articlesGoogle scholar articles
  • Chengxu Li Department of Dermatology, China-Japan Friendship Hospital, Beijing, China PubMed articlesGoogle scholar articles
  • Hiroaki Niiro Department of Medical Education, Kyushu University Graduate School of Medical Sciences, Fukuoka City, Japan PubMed articlesGoogle scholar articles
  • Youngho Park Hanyang University Institute for Rheumatology Research, Seoul, Korea PubMed articlesGoogle scholar articles
  • Changbing Shen Department of Dermatology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China Shenzhen Key Laboratory for Translational Medicine of Dermatology, Shenzhen Peking University - The Hong Kong University of Science and Technology Medical Center, Shenzhen, Guangdong, China PubMed articlesGoogle scholar articles
  • Takeshi Miyamoto Department of Orthopaedic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan PubMed articlesGoogle scholar articles
  • Ga-Young Ahn Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea PubMed articlesGoogle scholar articles
  • Wenmin Fei Department of Dermatology, China-Japan Friendship Hospital, Beijing, China PubMed articlesGoogle scholar articles
  • Tsutomu Takeuchi Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan PubMed articlesGoogle scholar articles
  • Jung-Min Shin Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea PubMed articlesGoogle scholar articles
  • Keke Li Department of Dermatology, China-Japan Friendship Hospital, Beijing, China PubMed articlesGoogle scholar articles
  • Yasushi Kawaguchi Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan PubMed articlesGoogle scholar articles
  • Yeon-Kyung Lee Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea PubMed articlesGoogle scholar articles
  • Yongfei Wang Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong, China PubMed articlesGoogle scholar articles
  • Koichi Amano Department of Rheumatology & Clinical Immunology, Saitama Medical Center, Saitama Medical University, Saitama, Japan PubMed articlesGoogle scholar articles
  • Dae Jin Park Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea PubMed articlesGoogle scholar articles
  • Wanling Yang Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong, China PubMed articlesGoogle scholar articles
  • Yoshifumi Tada Department of Rheumatology, Faculty of Medicine, Saga University, Saga, Japan PubMed articlesGoogle scholar articles
  • Ken Yamaji Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan PubMed articlesGoogle scholar articles
  • Masato Shimizu Hokkaido Medical Center for Rheumatic Disease, Hokkaido, Japan PubMed articlesGoogle scholar articles
  • Takashi Atsumi Department of Orthopaedic Surgery, Showa University School of Medicine, Tokyo, Japan PubMed articlesGoogle scholar articles
  • Akari Suzuki Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan PubMed articlesGoogle scholar articles
  • Takayuki Sumida Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan PubMed articlesGoogle scholar articles
  • Yukinori Okada Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPi-iFReC), Osaka University, Osaka, Japan PubMed articlesGoogle scholar articles
  • Koichi Matsuda Laboratory of Genome Technology, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan Laboratory of Clinical Genome Sequencing, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan PubMed articlesGoogle scholar articles
  • Keitaro Matsuo Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan Department of Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan PubMed articlesGoogle scholar articles
  • Yuta Kochi Department of Genomic Function and Diversity, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan PubMed articlesGoogle scholar articles
  • Japanese Research Committee on Idiopathic Osteonecrosis of the Femoral Head
    Google scholar articles
  • Leah C Kottyan Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio, USA PubMed articlesGoogle scholar articles
  • Matthew T Weirauch Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio, USA PubMed articlesGoogle scholar articles
  • Sreeja Parameswaran Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA PubMed articlesGoogle scholar articles
  • Shruti Eswar Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA PubMed articlesGoogle scholar articles
  • Hanan Salim Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA PubMed articlesGoogle scholar articles
  • Xiaoting Chen Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA PubMed articlesGoogle scholar articles
  • Kazuhiko Yamamoto Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan PubMed articlesGoogle scholar articles
  • John B Harley Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio, USA US Department of Veterans Affairs Medical Center, Cincinnati, Ohio, USA PubMed articlesGoogle scholar articles
  • Koichiro Ohmura Department of Rheumatology and Clinical immunology, Kyoto University Graduate school of Medicine, Kyoto, Japan PubMed articlesGoogle scholar articles
  • Tae-Hwan Kim Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea Hanyang University Institute for Rheumatology Research, Seoul, Korea PubMed articlesGoogle scholar articles
  • Sen Yang Department of Dermatology, First Affiliated Hospital, Anhui Medical University, Hefei, Anhui, China Institute of Dermatology, Anhui Medical University, Hefei, Anhui, China Key Lab of Dermatology, Ministry of Education (Anhui Medical University), Hefei, Anhui, China PubMed articlesGoogle scholar articles
  • Takuaki Yamamoto Department of Orthopaedic Surgery, Faculty of Medicine, Fukuoka University, Fukuoka, Japan PubMed articlesGoogle scholar articles
  • Bong-Jo Kim Division of Genome Research, Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Cheongju, Korea PubMed articlesGoogle scholar articles
  • Nan Shen Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University, School of Medicine (SJTUSM), Shanghai, China State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, China PubMed articlesGoogle scholar articles
  • Shiro Ikegawa Laboratory for Bone and Joint Diseases, RIKEN Center for Medical Sciences, Kanagawa, Japan PubMed articlesGoogle scholar articles
  • Hye-Soon Lee Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea Hanyang University Institute for Rheumatology Research, Seoul, Korea PubMed articlesGoogle scholar articles
  • Xuejun Zhang Department of Dermatology, First Affiliated Hospital, Anhui Medical University, Hefei, Anhui, China Institute of Dermatology, Anhui Medical University, Hefei, Anhui, China Key Lab of Dermatology, Ministry of Education (Anhui Medical University), Hefei, Anhui, China Department of Dermatology, Institute of Dermatology, Huashan Hospital, Fudan University, Shanghai, China PubMed articlesGoogle scholar articles
  • Chikashi Terao Laboratory for Statistical and Translational Genetics Analysis, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan Clinical Research Center, Shizuoka General Hospital, Shizuoka, Japan The Department of Applied Genetics, The School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan PubMed articlesGoogle scholar articles
  • Yong Cui Department of Dermatology, China-Japan Friendship Hospital, Beijing, China PubMed articlesGoogle scholar articles
  • Sang-Cheol Bae Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea Hanyang University Institute for Rheumatology Research, Seoul, Korea PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Chikashi Terao, Laboratory for Statistical and Translational Genetics Analysis, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan; chikashi.terao{at}riken.jp; Professor Yong Cui, Department of Dermatology, China-Japan Friendship Hospital, Beijing, China; wuhucuiyong{at}vip.163.com; Professor Sang-Cheol Bae, Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, The Republic of Korea; scbae{at}hanyang.ac.kr
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Citation

Yin X, Kim K, Suetsugu H, et al
Meta-analysis of 208370 East Asians identifies 113 susceptibility loci for systemic lupus erythematosus
Annals of the Rheumatic Diseases 2021;80:632-640.

Publication history

  • Received September 30, 2020
  • Revised November 4, 2020
  • Accepted November 11, 2020
  • First published December 3, 2020.
Online issue publication 
April 12, 2021

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.