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Candidate rheumatologic treatments for COVID-19. Response to: ‘COVID-19 infection in a patient with FMF: does colchicine have a protective effect?’ by Kobak
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  1. Sara Monti,
  2. Carlomaurizio Montecucco
  1. Rheumatology, Fondazione IRCCS Policlinico San Matteo, Pavia 27100, Italy
  1. Correspondence to Dr Sara Monti, Rheumatology, Fondazione IRCCS Policlinico San Matteo, Pavia 27100, Italy; sara.saramonti{at}gmail.com

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We appreciate the comment from Dr Kobak1 to our previously published report on the clinical course and outcome of COVID-19 in a cohort of patients treated with biologic and targeted synthetic disease modifying antirheumatic drugs.2 The author described the case of a patient with familial Mediterranean fever treated with colchicine who experienced a mild course of COVID-19. Although the effects of colchicine on the clinical course of COVID-19 on large-scale populations are still unknown, colchicine is one of the numerous rheumatologic treatments being tested against severe acute respiratory syndrome coronavirus-2, given its effects on the inflammasome and interleukin and cytokine activation.3 To date, there are at least 11 studies registered on clinicaltrials.gov to test the effects of colchicine on COVID-19. While we await for the results of these trials, the report by Dr Kobak offers further reassuring impressions on the clinical course of COVID-19 in patients treated with various types of antirheumatic agents.

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Footnotes

  • Handling editor Josef S Smolen

  • Contributors SM and CM contributed equally to the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting or dissemination plans of this research.

  • Patient consent for publication Not required.

  • Provenance and peer review Commissioned; internally peer reviewed.

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