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We appreciate the comment from Dr Kobak1 to our previously published report on the clinical course and outcome of COVID-19 in a cohort of patients treated with biologic and targeted synthetic disease modifying antirheumatic drugs.2 The author described the case of a patient with familial Mediterranean fever treated with colchicine who experienced a mild course of COVID-19. Although the effects of colchicine on the clinical course of COVID-19 on large-scale populations are still unknown, colchicine is one of the numerous rheumatologic treatments being tested against severe acute respiratory syndrome coronavirus-2, given its effects on the inflammasome and interleukin and cytokine activation.3 To date, there are at least 11 studies registered on clinicaltrials.gov to test the effects of colchicine on COVID-19. While we await for the results of these trials, the report by Dr Kobak offers further reassuring impressions on the clinical course of COVID-19 in patients treated with various types of antirheumatic agents.
Handling editor Josef S Smolen
Contributors SM and CM contributed equally to the manuscript.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting or dissemination plans of this research.
Patient consent for publication Not required.
Provenance and peer review Commissioned; internally peer reviewed.
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