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Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterised by immune inflammation.1 Autoimmune haemolytic anaemia (AIHA) is a pathological state in which antibodies attack red blood cells. AIHA and SLE shared genetic and environmental risk factors and pathophysiological mechanisms.2 AIHA is clearly over-represented in patients with SLE and often occurs before a diagnosis of SLE.3 However, at present, studies on the incidence of SLE in patients with AIHA are scarce. Therefore, we explored the correlation between AIHA and SLE risk in a nationwide, population-based, matched cohort study.
In the 2003–2013 Taiwanese National Health Insurance Database, we identified patients newly diagnosed with AIHA between 2005 and 2012 (online supplemental figure S1). We selected age-matched and sex-matched (1:20) non-AIHA cohort from one million representative populations. From this cohort, we further selected a comparison group via propensity-score matching (PSM, 1:2) for age, sex, comorbidities and possible confounders using the greedy algorithm (online supplemental methods). Ultimately, we identified 713 patients with AIHA and 1416 PSM-matched individuals …
Handling editor Josef S Smolen
H-YM and JCCW contributed equally.
Contributors H-YM and JCCW conceptualised the research and drafted the manuscripts. X-HC interpreted the data and drafted the manuscript. H-HC contributed to the research design, performed data analysis and graph generation and critically revised the manuscript. All authors have read and approved the final manuscript.
Funding This work was supported by funding from Chung Shan Medical University Hospital grant number CSH-2018-C-023 and the National Natural Science Foundation of China Grants [81 760 298].
Competing interests None declared.
Patient and public involvement The requirement for informed consent was waived because personal details were completely anonymised before analysis of data.
Patient consent for publication Not required.
Ethics approval This study was approved by the Institutional Review Board of Taichung Veterans General Hospital in Taiwan (approval number: CE17100B).
Provenance and peer review Not commissioned; externally peer reviewed.