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Combined genetic analysis of juvenile idiopathic arthritis clinical subtypes identifies novel risk loci, target genes and key regulatory mechanisms

Authors

  • Elena López-Isac Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK PubMed articlesGoogle scholar articles
  • Samantha L Smith Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK PubMed articlesGoogle scholar articles
  • Miranda C Marion Center for Public Health Genomics and Department of Biostatistical Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA PubMed articlesGoogle scholar articles
  • Abigail Wood Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK PubMed articlesGoogle scholar articles
  • Marc Sudman Division of Rheumatology, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, Ohio, USA PubMed articlesGoogle scholar articles
  • Annie Yarwood Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK PubMed articlesGoogle scholar articles
  • Chenfu Shi Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK PubMed articlesGoogle scholar articles
  • Vasanthi Priyadarshini Gaddi Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK PubMed articlesGoogle scholar articles
  • Paul Martin Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK The Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, Manchester, UK PubMed articlesGoogle scholar articles
  • Sampath Prahalad Department of Pediatrics and Human Genetics, Emory University, and Children’s Healthcare of Atlanta, Atlanta, Georgia, USA PubMed articlesGoogle scholar articles
  • Stephen Eyre Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK National Institute of Health Research Manchester Biomedical Research Centre, Manchester Academic Health Science Centre, Manchester University NHS Foundation Trust, Manchester, Greater Manchester, UK PubMed articlesGoogle scholar articles
  • Gisela Orozco Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK National Institute of Health Research Manchester Biomedical Research Centre, Manchester Academic Health Science Centre, Manchester University NHS Foundation Trust, Manchester, Greater Manchester, UK PubMed articlesGoogle scholar articles
  • Andrew P Morris Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK PubMed articlesGoogle scholar articles
  • Carl D Langefeld Center for Public Health Genomics and Department of Biostatistical Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA PubMed articlesGoogle scholar articles
  • Susan D Thompson Division of Rheumatology, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, Ohio, USA PubMed articlesGoogle scholar articles
  • Wendy Thomson Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK National Institute of Health Research Manchester Biomedical Research Centre, Manchester Academic Health Science Centre, Manchester University NHS Foundation Trust, Manchester, Greater Manchester, UK PubMed articlesGoogle scholar articles
  • John Bowes Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK National Institute of Health Research Manchester Biomedical Research Centre, Manchester Academic Health Science Centre, Manchester University NHS Foundation Trust, Manchester, Greater Manchester, UK PubMed articlesGoogle scholar articles
  1. Correspondence to Dr John Bowes, Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK; j.bowes{at}manchester.ac.uk
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Citation

López-Isac E, Smith SL, Marion MC, et al
Combined genetic analysis of juvenile idiopathic arthritis clinical subtypes identifies novel risk loci, target genes and key regulatory mechanisms

Publication history

  • Received July 1, 2020
  • Revised August 28, 2020
  • Accepted September 16, 2020
  • First published October 26, 2020.
Online issue publication 
February 11, 2021

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