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Psoriatic arthritis (PsA) is a chronic, inflammatory and immune-mediated disease that affects up to 30% of psoriasis (PsO) patients.1 Nail involvement affects 80% of PsA patients and 30%–50% of PsO patients. Nail PsO has been associated with worse quality of life, higher score on the PsO Area Severity Index, early disease onset, arthritis, depression and anxiety.2 Patients with PsO and PsA have a higher risk of cardiovascular atherosclerotic morbidity and mortality than the general population. Nail PsO and cardiovascular disease have been seldom studied. Nail involvement in PsO patients has been associated to a higher prevalence of metabolic syndrome, higher risk of heart failure and higher cardiovascular risk overall.3 4 If PsA patients with nail PsO also have a higher cardiovascular risk is unknown. We aimed to determine if nail involvement in PsA patients is associated with a higher prevalence of subclinical atherosclerosis by carotid ultrasound.
We performed a cross-sectional, observational and comparative study that included a total of 64 PsA patients consecutively recruited from …
Handling editor Josef S Smolen
Twitter @DraIrisColungaReuma, @aleberenice19
Contributors All authors had access to the data and a role in writing the manuscript. IJC-P, DAG-D, JRA-L, ABR-R and NG-J contributed to the study conception and design. Data collected by ABR-R, NG-J, SL-P, AM-G, JL-A and ACG-A. Statiscal analyses were performed by ABR-R, NG-J and JAC-dlG. Writing of the first draft was performed by ABR-R, NG-J and JAC-dlG. All authors commented on posterior versions of the manuscript. All authors read and approved the final manuscript.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.
Provenance and peer review Not commissioned; externally peer reviewed.