Article Text

Download PDFPDF

Correction: Dual neutralisation of interleukin-17A and interleukin-17F with bimekizumab in patients with active ankylosing spondylitis: results from a 48-week phase llb, randomised, double blind, placebo-controlled, dose-ranging study

Statistics from Altmetric.com

Van der Heijde D, Gensler LS, Deodhar, et al. Dual neutralisation of interleukin-17A and interleukin-17F with bimekizumab in patients with active ankylosing spondylitis: results from a 48-week phase llb, randomised, double blind, placebo-controlled, dose-ranging study. Ann Rheum Dis 2020;79:595–604. doi: 10.1136/annrheumdis-2020-216980

The authors have been made aware that one patient initially randomised to the bimekizumab 320 mg group withdrew from the study during the dose-blind period due to an event of oral candidiasis. Therefore, the current article contains an error in the Safety section of the Results and Discussion section:

In both instances, the statements regarding the lack of study withdrawals/discontinuations due to oral candidiasis are incorrect, as one patient withdrew from the study due to oral candidiasis.

The correct text should state:

Safety section of the Results

Oral candidiasis was reported by 3 (4.9%) patients in the bimekizumab 320 mg group during the double-blind period (table 5) and 16/303 (5.3%) of bimekizumab-treated patients in total. All cases were mild to moderate, none were serious, and resolved with systemic or topical antifungal treatment. One patient withdrew from the study during the dose-blind period due to oral candidiasis.

Discussion

Consistent with the mechanism of action of therapies targeting the IL-17 pathway, 16 cases (5%) of oral candidiasis were reported in bimekizumab-treated patients across the 48 weeks of treatment.11 33 However, all cases were mild or moderate, and most did not lead to discontinuation.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Linked Articles