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Response to: ‘Alcohol is not the missing link between Porphyromonas gingivalis related periodontitis and radiologic progression in early Rheumatoid arthritis’ by Hillion et al
  1. Hubert Marotte1,2,
  2. Stéphane Paul3
  1. 1 Rhumatologie, CHU Saint-Etienne, Saint-Etienne, France
  2. 2 SAINBIOSE, INSERM U1059, University of Lyon, Saint-Etienne, France
  3. 3 Laboratory of Immunology and Immunomonitoring, Universite Jean Monnet Saint-Etienne Faculte de Medecine Jacques Lisfranc, Saint Priest en Jarez, France
  1. Correspondence to Professor Hubert Marotte, Rhumatologie, CHU Saint-Etienne, Saint-Etienne 42055, France; hubert.marotte{at}

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We appreciate the comments by Hillion et al 1 on our original paper.2 The data presented are very interesting and suggest that P. gingivalis serology positive was not associated to early rheumatoid arthritis (RA) severity in the ESPOIR cohort. They also tested interactions between gender, P. gingivalis serology status and radiological progression. They observed only a trend for interaction between P. gingivalis serology status and radiological progression.3 Since, smoking status and HLA-DRB1 shared epitope are also major risk factors for chronic periodontitis,4 we suggest to Hillion et al 1 to check interactions with smoking and HLA status. In the ESPOIR cohort, level of anti-P. gingivalis was increased in patients who had never smoked and that increased levels of these antibodies were associated with more erosive disease.5 Hillion et al 1 provided only a partial assessment of periodontal status only based on P. gingivalis serology status without assessment of another periodontal germ as Prevotella intermedia.



  • Handling editor Josef S Smolen

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Provenance and peer review Commissioned; internally peer reviewed.

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