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Sarcoidosis is an immune inflammatory disorder characterised by the presence of granulomatous tissue and can involve one or multiple organs. Glucocorticoids are a mainstay of treatment, but in some patients the maintenance steroid dose can be elevated for daily use and usually immunosuppressive medications such as methotrexate or mycophenolate is associated. In the presence of progressive disease anti-tumour necrosis factors (TNFs) have also been used with apparent success although controlled trials are not available.1
The rheumatologist can be the first speciality to evaluate such patients when articular or extra-articular symptoms are initial modes of presentation.2 Janus kinase (JAK) signal transducer and activator of transcription signalling have been shown to be highly expressed in sarcoid tissue and maybe responsible …
Handling editor Josef S Smolen
Contributors Patient care diagnostic conclusion preparing manuscript.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting or dissemination plans of this research.
Patient consent for publication Not required.
Ethics approval This study was approved by the Ethical Committee of the Hospital Beneficencia Portuguesa de Sao Paulo.
Provenance and peer review Not commissioned; externally peer reviewed.
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