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Response to: ‘Blood plasma versus serum: which is right for sampling circulating membrane microvesicles in human subjects?’ by Liu et al
  1. Yasuhiro Kato1,2,
  2. JeongHoon Park2,3,
  3. Hyota Takamatsu1,2,
  4. Atsushi Kumanogoh1,2
  1. 1 Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita City, Japan
  2. 2 Laboratory of Immunopathology, WPI Immunology Frontier Research Center, Suita City, Japan
  3. 3 Graduate School of Medicine, Osaka University, Suita City, Japan
  1. Correspondence to Dr Hyota Takamatsu, Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan; thyota{at}

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The correspondence on our study is very much appreciated.1 We have shown that the microvesicles (MVs) in the serum from patients with systemic lupus erythematisus *(SLE) contain higher concentration of double strand DNA (dsDNA) and have higher interferon-stimulated gene (ISG)-inducing activity than healthy controls. In the letter from Liu et al, authors addressed several concerns regarding the use of serum-derived MVs in experiments since these may not represent the physiological MVs present in the circulation of patients with SLE.2 We agree that plasma is preferable for the preparation of MVs. However, reporter activity could not be evaluated using …

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