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  • Histopathological subgrouping versus renal risk score for the prediction of end-stage renal disease in ANCA-associated vasculitis

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Histopathological subgrouping versus renal risk score for the prediction of end-stage renal disease in ANCA-associated vasculitis
  1. Onay Gercik1,
  2. Emre Bilgin2,
  3. Dilek Solmaz3,
  4. Fulya Cakalagaoglu4,
  5. Arzu Saglam5,
  6. Ozge Aybi2,
  7. Riza Can Kardas2,
  8. Zeki Soypacaci6,
  9. Gokhan Kabadayi3,
  10. Tolga Yildirim7,
  11. Idil Kurut Aysin3,
  12. Omer Karadag2,
  13. Servet Akar8
  1. 1 Rheumatology, Izmir Katip Celebi University Faculty of Medicine, Izmir, Turkey
  2. 2 Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey
  3. 3 Rheumatology, Izmir Katip Celebi University Faculty of Medicine, Izmirs, Turkey
  4. 4 Pathology, Izmir Katip Celebi University Faculty of Medicine, Izmir, Turkey
  5. 5 Pathology, Hacettepe University Faculty of Medicine, Ankara, Turkey
  6. 6 Nephrology, Izmir Katip Celebi University Faculty of Medicine, Izmir, Turkey
  7. 7 Nephrology, Hacettepe University Faculty of Medicine, Ankara, Turkey
  8. 8 Department of Internal Medicine, Division of Rheumatology, Izmir Katip Celebi University Faculty of Medicine, Izmir, Turkey
  1. Correspondence to Professor Servet Akar, Department of Internal Medicine, Division of Rheumatology, Izmir Katip Celebi University Faculty of Medicine, 35620 Çiğli/İzmir, Turkey; servet.akar{at}gmail.com

http://dx.doi.org/10.1136/annrheumdis-2019-216742

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    In patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV) and renal involvement, the development of end-stage renal disease (ESRD) remains an undesired issue. To date, reported predictors of renal outcome are mainly patients’ age, severe renal dysfunction and histopathological findings at presentation.1 2 Histopathological classification as defined by Berden et al was proposed to be helpful with the highest renal survival rates in the focal group and the poorest in the sclerotic group.3 4 Recently, Brix et al suggested the antineutrophil cytoplasmic antibody renal risk score (ARRS) to predict ESRD in patients with AAV.5 Unlike Berden's classification, ARRS combines histopathological findings (the percentage of normal glomeruli, tubular atrophy and interstitial fibrosis) with baseline glomerular filtration rate (GFR). Here, we aimed to assess the prognostic factors for renal survival and to evaluate the performances of Berden’s histopathological classification and ARRS for predicting ESRD.

    We reviewed the medical records of all patients diagnosed …

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    Footnotes

    • Handling editor Josef S Smolen

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.

    • Patient consent for publication Not required.

    • Provenance and peer review Not commissioned; externally peer reviewed.