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I read with great interest the article by Zhao and Schooling1 regarding the role of linoleic acid in autoimmune disorders. This Mendelian randomisation (MR) analysis suggests that linoleic acid protects against rheumatoid arthritis (RA). However, it has a methodological issue. The choice of the genetic instrumental variables (IV) is essential for a successful MR study. MR analyses using multiple genetic variants can be viewed as a meta-analysis of the causal estimates from each variant.2 The availability of estimates of both the gene-risk factor and the gene-outcome …
Handling editor Josef Smolen
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Patient consent Not required.
Provenance and peer review Not commissioned; internally peer reviewed.
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