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Handling editor Josef S Smolen
Contributors MLU, FM and AV designed the study, analysed the data and drafted the manuscript. MLU, FM, AP, PF, F Peyronel, GT, SF, CDB, PCG, GE and AV followed the patients and collected the data. F Pegoraro and MLU generated the figures. PCG, DP, PR and GE critically reviewed the manuscript.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Patient and public involvement statement Given the retrospective nature of this work, it was not possible to involve patients or the public in the design, or conduct, or reporting, or dissemination of this research.
Patient consent for publication Not required.
Provenance and peer review Not commissioned; externally peer reviewed.