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Effectiveness of low-dose radiation therapy on symptoms in patients with knee osteoarthritis
  1. Xiang-Dong Wu1,
  2. Ke-Jia Hu2,
  3. Bing-Yan Xiang3,
  4. Wei Huang1
  1. 1 Department of Orthopaedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
  2. 2 Center of Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
  3. 3 Department of Orthopaedic Surgery, The First People's Hospital of Zunyi City, Zunyi, Guizhou Province, China
  1. Correspondence to Professor Wei Huang, Department of Orthopaedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China; drhuangwei68@gmail.com,huangwei68{at}263.net

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We read with interest the milestone work in the Annals of the Rheumatic Diseases by Mahler and colleagues1 on the effectiveness of low-dose radiation therapy (LDRT) on symptoms in patients with knee osteoarthritis (OA). The authors have conducted a series of studies to investigate the effects of LDRT on OA, which compensate the lack of high-level evidence in the medical literature, and inevitably forcing us to re-examine the true effectiveness of LDRT on OA in real-world clinical practice.1–3 The group should be applauded for their accomplishments. In this well-designed and well-conducted randomised, double-blinded, sham-controlled trial, they found no substantial beneficial effect on symptoms and …

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Footnotes

  • Handling editor Josef Smolen

  • Contributors X-DW contributed substantially to conception and design; drafted the article; gave final approval of the version to be published; agreed to act as guarantor of the work. K-JH contributed substantially to drafting the article; gave final approval of the version to be published; agreed to act as guarantor of the work. B-YX contributed substantially to drafting the article; gave final approval of the version to be published; agreed to act as guarantor of the work. WH contributed substantially to conception and design; revised it critically for important intellectual content; gave final approval of the version to be published; agreed to act as guarantor of the work.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; internally peer reviewed.

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