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Methotrexate reduces withdrawal rates of TNF inhibitors due to ineffectiveness in rheumatoid arthritis but only in patients who are seropositive

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  • Handling editor Josef S Smolen

  • Twitter @MikeEhrenstein

  • Contributors MG and MRE were involved in the design of the study and data interpretation and wrote the manuscript. MG performed the research and collected and analysed the data. MS, S-AY, ER and DM collected, verified and analysed the validation cohort. All authors reviewed and approved the manuscript’s content before submission.

  • Funding MG (and MRE in part) are supported by the University College London Hospital Biomedical Research Centre (BRC420).

  • Competing interests None declared.

  • Patient and public involvement Patients and/or the public were not involved in the design, conduct, reporting or dissemination plans of this research.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.