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FRI0456 THE EFFECT OF GENDER ON DISEASE ACTIVITY, FUNCTIONAL INDEX AND QUALITY OF LIFE IN PATIENTS WITH AXIAL SPA. THE DATA OF TLAR-NETWORK PSA STUDY
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  1. Kemal Nas1,
  2. Erkan Kilic2,
  3. Ibrahim Tekeoğlu1,
  4. Remzi Cevik3,
  5. Betul Sargin4,
  6. Sevtap Acer Kasman5,
  7. Hakan Alkan6,
  8. Nilay Sahin7,
  9. Gizem Cengiz8,
  10. Nihan Cuzdan9,
  11. Ilknur Albayrak Gezer10,
  12. Dilek Keskin11,
  13. Cevriye Mülkoğlu12,
  14. Hatice Resorlu13,
  15. Şebnem Ataman14,
  16. Ajda Bal15,
  17. Mehmet Tuncay Duruöz5,
  18. Okan Kucukakkas16,
  19. Ozan Volkan Yurdakul16,
  20. Meltem Alkan Melikoglu17,
  21. Yıldıray Aydın1,
  22. Figen Ayhan18,
  23. Hatice Bodur19,
  24. Mustafa Calis8,
  25. Erhan Capkin20,
  26. Gul Devrimsel21,
  27. Kevser Gok22,
  28. Sami Hizmetli23,
  29. Ayhan Kamanlı1,
  30. Yasar Keskin16,
  31. Hilal Kocabas24,
  32. Oznur Kutluk25,
  33. Nesrin Şen26,
  34. Omer Faruk Sendur4,
  35. Murat Toprak27,
  36. Sena Tolu16,
  37. Tiraje Tuncer25
  1. 1Sakarya Unv, Sakarya, Turkey
  2. 2Afyon Hospt, Afyon, Turkey
  3. 3Dicle Unv, Diyarbakır, Turkey
  4. 4Adnan Menderes Unv, Aydın, Turkey
  5. 5Marmara Unv, İstanbul, Turkey
  6. 6Pamukkale Unv, Denizli, Turkey
  7. 7Balıkesir Unv, Balıkesir, Turkey
  8. 8Erciyes Unv, Kayseri, Turkey
  9. 9Şanlıurfa Hospt, Şanlıurfa, Turkey
  10. 10Selçuk Unv, Konya, Turkey
  11. 11Kırıkkale Unv, Kırıkkale, Turkey
  12. 12Ankara Traiand Res Hospt, Ankara, Turkey
  13. 13Çanakkale 18 Mart Unv, Çanakkale, Turkey
  14. 14Ankara Unv, Ankara, Turkey
  15. 15Dışkapı Traiand Res Hospt, Ankara, Turkey
  16. 16Bezmiâlem Unv, İstanbul, Turkey
  17. 17Atatürk Unv, Erzurum, Turkey
  18. 18Ankara TraiandRes Hospt, Ankara, Turkey
  19. 19Yıldırım Beyazıt Unv, Ankara, Turkey
  20. 20Karadeniz Tech Unv, Trabzon, Turkey
  21. 21Recep Tayyip Erdoğan Unv, Rize, Turkey
  22. 22Numune TraiandRes Hospt, Ankara, Turkey
  23. 23Cumhuriyet Unv, Sivas, Turkey
  24. 24Necmettin Erbakan Unv, Konya, Turkey
  25. 25Akdeniz Unv, Antalya, Turkey
  26. 26Kartal Dr. Lütfi Kırdar TraiandRes Hospt, İstanbul, Turkey
  27. 27Yuzuncu Yıl Unv, Van, Turkey

Abstract

Background PsA is a chronic musculoskeletal disease. The prevalence of axial involvement in PsA varies according to the duration of the disease. In early stage the incidence varies between 5% and 28%, but it increases up to 25-70% in later stages of the disease. In the literature, there is limited data on the differences in disease activity, functional status and quality of life of men and women with axial PsA.

Objectives In this study, we aimed to evaluate the effect of gender difference on clinical findings, disease activity, functional status and quality of life in patients with axial involvement in Turkey.

Methods Patients with PsA who met the CASPAR classification criteria were enrolled consequently in this cohort. Turkish League Against Rheumatism (TLAR)- Network was formed with the participation of 25 centers. The demographic variables, fatigue, diagnostic delay, the beginning of peripheral arthritis, enthesitis, dactylitis and spine involvement, inflammatory lumbar pain, patients’ quality of life, BASFI, HAQ, HAQ-s,VAS pain, anxiety, depression and disease activity parameters (TJC, SJC, ESH, DAS28, BASDAI), were recorded. Student’s t test and Chi-square test were used to compare variables in SPSS v.22 program.

Results A total of 1130 patients (36.0% male, 64.0% female) with PsA included in this study. In this cohort, 169 male (46 ± 12.29) and 251 female (47.4 ± 12.11) had axial involvement. VAS pain (p <0.001), fatigue (p <0.001), ESR (p <0.001), DAS28 (p <0.001), BASDAI score (p <0.001), PsAQoL (p <0.001), HAQ score (p <0.001), HAQ-S score (p <0.001), anxiety (p <0.001), depression (p <0.020), FACIT (p <0.001) and FIRST (p <0.001) scores were statistically significantly worse in women than males with axial PsA (Table 1). However, SF-36 physical component score (p <0.001), SF-36 mental component score (p <0.001) and PASI score (p <0.005) were statistically worse in male patients than in female patients with axial involvement.

Conclusion This study shown that the burden of disease in axial PsA has a significantly different between genders. Female patients with PsA who have axial involvement have higher disease activity, physical disability, functional limitation and higher depression and anxiety risk than male patients. Therefore, we suggest that new strategies should be developed for more effective treatment of axial PsA in female patients.

Disclosure of Interests Kemal Nas: None declared, Erkan Kilic: None declared, ibrahim tekeoğlu: None declared, Remzi Cevik: None declared, Betul Sargin: None declared, Sevtap Acer Kasman: None declared, Hakan Alkan: None declared, Nilay Sahin: None declared, Gizem Cengiz: None declared, Nihan Cuzdan: None declared, Ilknur Albayrak Gezer: None declared, Dilek Keskin: None declared, Cevriye Mülkoğlu: None declared, Hatice Resorlu: None declared, Şebnem Ataman: None declared, Ajda Bal: None declared, Mehmet Tuncay Duruöz Grant/research support from: Abvie, Speakers bureau: Novartis, AMGEN, Abdi İbrahim, İlko, Okan Kucukakkas: None declared, Ozan Volkan Yurdakul: None declared, Meltem Alkan Melikoglu: None declared, Yıldıray Aydın: None declared, Figen Ayhan: None declared, Hatice Bodur: None declared, Mustafa Calis: None declared, Erhan Capkin: None declared, Gul Devrimsel: None declared, Kevser Gok: None declared, SAMI HIZMETLI: None declared, Ayhan Kamanlı: None declared, Yasar Keskin: None declared, Hilal Kocabas: None declared, Oznur Kutluk: None declared, Nesrin Şen: None declared, Omer Faruk Sendur: None declared, Murat Toprak: None declared, Sena Tolu: None declared, Tiraje Tuncer: None declared

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