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  1. Cristina Reategui Sokolova1,2,
  2. Claudia Elera-Fitzcarrald1,3,
  3. Rocío Violeta Gamboa Cárdenas1,
  4. Mariela Medina1,
  5. Francisco Zevallos Miranda1,
  6. Paola Alejandra Zeña Huancas1,
  7. Victor Pimentel Quiroz1,
  8. Jorge-M Cucho-V1,
  9. Cesar Pastor Asurza1,4,
  10. Zoila Rodriguez Bellido1,4,
  11. Risto Perich Campos1,4,
  12. Graciela S Alarcon5,6,
  13. Manuel F. Ugarte-Gil1,3
  1. 1Hospital Nacional Guillermo Almenara Irigoyen, Lima, Peru
  2. 2Unidad para la Generación y Síntesis de Evidencias en Salud, Universidad San Ignacio de Loyola, Lima, Peru
  3. 3Universidad Científica del Sur, Lima, Peru
  4. 4Universidad Nacional Mayor de San Marcos, Lima, Peru
  5. 5University of Alabama at Birmingham, Birmingham, United States of America
  6. 6Universidad Peruana Cayetano Heredia, Lima, Peru


Background: Work disability in patients with systemic lupus erythematosus (SLE) is common but the factors associated with it in Low and Middle Income Countries have been scarcely evaluated(1).

Objectives: To determine the prevalence of and the factors associated with work disability in SLE patients.

Methods: We studied 239 consecutive (1997 American College of Rheumatology (ACR) criteria) patients from a Peruvian SLE cohort from October 2017 to December 2018. Work disability was measured from a single self-report questionnaire. Data were collected and included sociodemographic information, clinical lupus features including disease activity [Systemic Lupus Erythematosus Disease Activity Index 2000 update (SLEDAI-2K)], damage [Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI)], as well as Health-Related Quality of Life (LupusQoL), and medication use. Work disability was defined by patients’ self-report of not being able to work because of SLE. Univariable analysis comparing those patients with work disability and those who remained working were performed with the Mann Whitney U test for continuous variables and the Chi-square test for dichotomous variables. For the multivariable analyses, binary logistic regression with backward elimination was used to determine which factors remained associated with work disability.

Results: Of 239 patients, 194 patients were working at least for at least some time since diagnosis, 181 (93.0%) were female, they had a mean age at diagnosis of 34.5 (12.3) years, and a mean disease duration of 11.5 (7.4) years, their mean SLEDAI was 2.53 (3.7) and their mean SDI was 1.2 (1.5). Twenty-eight patients changed their activities at work due to SLE and 51 (26.6%) stopped working after their diagnosis; 21 of them (41.1%) stopped working because of SLE. One hundred and forty-three were working at the time of the evaluation. In the multivariate analyses, those work- disabled due to SLE were more likely to have higher SDI: OR=1.650 (CI95%: 1.134-2.403) p=0.009, and lower HRQoL in two domains, planning: OR=0.975 (CI 95%: 0.954-0.996) p=0.020 and body image OR=0.977 (CI95%: 0.956, 0.998), p=0.032.

Conclusion: Work disability due to SLE is associated with higher damage accrual and a poorer HRQoL.

References: [1] Mak A. The economic burden of systemic lupus erythematosus in Asia: the current state. Sing Lau C, editor. Lupus. 2010Oct14;19(12):1442–6.

Disclosure of Interests: None declared

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