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THU0283 PATIENT ACCEPTABLE SYMPTOMS STATE (PASS) QUESTIONNAIRE APPLICATION IN THE COHORT OF SLE PATIENTS FROM THE SPANISH SOCIETY OF RHEUMATOLOGY (RELESSER): ASSOCIATION WITH ACTIVITY INDEX
  1. Tomas Vazquez Rodriguez1,
  2. Iñigo Rua Figueroa2,
  3. Victor Del Campo Pérez3,
  4. J. Narváez4,
  5. Francisco J López-Longo5,
  6. María Galindo-Izquierdo6,
  7. Jaime Calvo-Alen7,
  8. Antonio Fernandez-Nebro8,
  9. Juan Ovalles9,
  10. Pilar Rubio Muñoz10,
  11. Eva Tomero Muriel11,
  12. Coral Mouriño Rodríguez3,
  13. Esther Uriarte Isacelaya12,
  14. Angela Pecondon-Español13,
  15. Mercedes Freire González14,
  16. Ricardo Blanco15,
  17. Marian Gantes Mora16,
  18. Mónica Ibañez Barceló17,
  19. Carlos A. Montilla-Morales18,
  20. Jose M Pego-Reigosa3,
  21. RELESSER (Spanish Society of Rheumatology Lupus Registry)
  1. 1HOSPITAL LUCUS AUGUSTI, LUGO, Spain
  2. 2HOSPITAL GRAN CANARIA DR NEGRIN, Gran Canaria, Spain
  3. 3COMPLEJO HOSPITALARIO UNIVERSITARIO DE VIGO, Vigo, Spain
  4. 4HOSPITAL DE BELLVITGE, Barcelona, Spain
  5. 5HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN, MADRID, Spain
  6. 6HOSPITAL UNIVERSITARIO 12 DE OCTUBRE, Madrid, Spain
  7. 7HOSPITAL UNIVERSITARIO ARABA, Alava, Spain
  8. 8HOSPITAL REGIONAL UNIVERSITARIO DE MÁLAGA, Malaga, Spain
  9. 9HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN, Madrid, Spain
  10. 10HOSPITAL GERMANS TRIAS I PUJOL, Badalona, Spain
  11. 11HOSPITAL DE LA PRINCESA, Madrid, Spain
  12. 12HOSPITAL DE DONOSTIA, Donostia, Spain
  13. 13HOSPITAL MIGUEL SERVET, Zaragoza, Spain
  14. 14HOSPITAL JUAN CANALEJO A CORUÑA, A Coruña, Spain
  15. 15HOSPITAL MARQUÉS DE VALDECILLA, Santander, Spain
  16. 16HOSPITAL UNIVERSITARIO DE CANARIAS, Las Palmas de Gran Canaria, Spain
  17. 17HOSPITAL SON LLÀTZER, Mallorca, Spain
  18. 18HOSPITAL CLÍNICO UNIVERSITARIO SALAMANCA, Salamanca, Spain

Abstract

Background Little is known about the patient related outcomes and disease activity in systemic lupus erythematosus. Damage and impact are issues that have not been associated with activity in lupus previously.

Objectives In a large cohort of systemic lupus erythematosus (SLE) patients, to evaluate the association between a Patient Acceptable Symptom State (PASS) and three different domains of the disease: activity, damage and impact of SLE on patients’ lives

Methods Cross-sectional study of 1,364 SLE (ACR 97 Criteria) patients from the Spanish Society of Rheumatology Lupus Registry (RELESSER). Patients were clinically assessed by the physicians, who collected data about demographics, clinical manifestations, laboratory features and therapies. SLE activity was assessed by using the SLEDAI (SLE Disease Activity Index). The Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SLICC/ACR DI) was used to measure damage accrual. The impact of SLE on patients’ lives was evaluated by using the Lupus Impact Tracker (LIT). The PASS question “Considering all the different ways your disease is affecting you, if you would stay in this state for the next months, do you consider that your current state is satisfactory?” was answered in a dichotomized way: yes/no. Measures of central tendency and spread were used to describe responses and T-test was used to evaluate the independence between PASS and the other questionnaires and indices.

Results Mean age (years) ± S.D. of the 1,364 patients included in the study was 49.9 ± 13.3; 90.3% were female and 94.9% were Caucasian. In the total of patients, 979 (71.8%) were in PASS. Patients in PASS had significantly lower activity (SLEDAI Score) than those not in PASS (2.4 ± 3.2 vs. 3.0 ± 3.9, respectively; p=0.007). The SLICC/ACR DI was significantly lower in the group of patients in PASS compared to those without PASS (0.64 ± 1.1 vs. 0.81 ± 0.21, respectively; p=0.022). SLE had a significantly lower impact on patients in PASS in comparison to those without PASS (LIT Score: 8.47 ± 7.5 vs. 19.8 ± 8.34, respectively; p=0.001).

Conclusion In the largest observational European Registry of SLE patients, PASS was associated with other domains of the disease: activity, damage and impact on patients’ life. PASS is a simple and reliable patient-reported outcome that can be a useful tool to evaluate patients’ well-being.

Disclosure of Interests Tomas Vazquez Rodriguez: None declared, Iñigo Rua Figueroa: None declared, Victor Del Campo Pérez: None declared, J. Narváez Consultant for: Bristol-Myers Squibb, Francisco J López-Longo: None declared, María Galindo-Izquierdo: None declared, Jaime Calvo-Alen: None declared, Antonio Fernandez-Nebro: None declared, Juan Ovalles: None declared, Pilar Rubio Muñoz: None declared, Eva Tomero Muriel: None declared, Coral Mouriño Rodríguez: None declared, Esther Uriarte Isacelaya: None declared, Angela Pecondon-Español: None declared, Mercedes Freire González: None declared, Ricardo Blanco Grant/research support from: Abbvie, MSD, and Roche, Consultant for: Abbvie, Pfizer, Roche, Bristol-Myers, Janssen, Speakers bureau: Abbvie, Pfizer, Roche, Bristol-Myers, Janssen, Marian Gantes Mora: None declared, Mónica Ibañez Barceló: None declared, Carlos A. Montilla-Morales: None declared, Jose M Pego-Reigosa: None declared

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