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  1. Seungmin Jung,
  2. Juyoung Yoo,
  3. Sungsoo Ahn,
  4. Sangwon Lee,
  5. Jason Jungsik Song,
  6. Yongbeom Park
  1. Yonsei University College of Medicine, Internal Medicine, Seoul, Korea, Rep. of (South Korea)


Background: Anti-Smith (Sm) antibody is a highly specific antibody for systemic lupus erythematosus (SLE). Despite the remarkable specificity of anti-Sm antibodies for SLE, the association between anti-Sm antibody level and the clinical manifestation of SLE is still unclear.

Objectives: We aimed to evaluate the association between anti-Sm antibodies and disease activity in patients with new-onset SLE.

Methods: We included patients who were repeatedly tested for anti-Sm antibodies at SLE diagnosis and within 12 months after SLE diagnosis. The clinical and laboratory profiles, and SLE disease activity index (SLEDAI) were collected at the time of the anti-Sm antibody test. SLEDAI and laboratory variables associated with disease activity were compared at baseline between patients with and without anti-Sm antibodies. The longitudinal association between disease activity and anti-Sm antibodies was also evaluated in total patients and in those with anti-Sm antibodies.

Results: Of 92 patients who were tested for anti-Sm antibodies at the time of SLE diagnosis, 67 and another 67 patients were followed up for the presence of anti-Sm antibodies at 6 and 12 months, respectively. Although the baseline SLEDAI was comparable in SLE patients with and without anti-Sm antibodies, the serum anti-Sm antibody level at diagnosis was significantly correlated with SLEDAI (P = 0.003). Patients with anti-Sm antibodies at 12 months had higher SLEDAI and anti-dsDNA levels than those without anti-Sm antibodies (P = 0.002, respectively). The changes in anti-Sm antibody levels over 12 months were also correlated with the alterations in SLEDAI (P = 0.029).

Conclusion: This study suggests that anti-Sm antibody level is associated with disease activity in patients with new-onset SLE, and that monitoring of anti-Sm antibody levels could help assess the disease activity.

References [1] Migliorini, P., et al., Anti-Sm and anti-RNP antibodies. Autoimmunity, 2005. 38(1): p. 47-54.

[2] Clinical associations of anti-Smith antibodies in PROFILE: a multi-ethnic lupus cohort. Clin Rheumatol, 2015. 34(7): p. 1217-23.

[3] What is the clinical significance of anti-Sm antibodies in systemic lupus erythematosus? A comparison with anti-dsDNA antibodies and C3. Clin Exp Rheumatol, 2017. 35(4): p. 598-606.

Disclosure of Interests: None declared

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