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SAT0382 THE RISK FACTORS RELATED TO MENTAL HEALTH PROBLEMS IN PATIENTS WITH PSORIATIC ARTHRITIS IN A LARGE MULTICENTER STUDY; DATA FROM TLAR-NETWORK
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  1. Gamze Kiliç1,
  2. Kemal Nas2,
  3. Erkan Kilic3,
  4. Ibrahim Tekeoğlu2,
  5. Betul Sargin4,
  6. Sevtap Acer Kasman5,
  7. Hakan Alkan6,
  8. Nilay Sahin7,
  9. Gizem Cengiz8,
  10. Nihan Cuzdan9,
  11. Ilknur Albayrak Gezer10,
  12. Dilek Keskin11,
  13. Cevriye Mülkoğlu12,
  14. Hatice Resorlu13,
  15. Şebnem Ataman14,
  16. Ajda Bal15,
  17. Mehmet Tuncay Duruöz5,
  18. Okan Kucukakkas16,
  19. Ozan Volkan Yurdakul16,
  20. Meltem Alkan Melikoglu17,
  21. Yildiray Aydin2,
  22. Figen Ayhan12,
  23. Hatice Bodur18,
  24. Mustafa Calis8,
  25. Erhan Capkin19,
  26. Gul Devrimsel20,
  27. Sami Hizmetli21,
  28. Ayhan Kamanli2,
  29. Kevser Gok22,
  30. Yasar Keskin16,
  31. Hilal Kocabas23,
  32. Oznur Kutluk24,
  33. Nesrin Şen25,
  34. Omer Faruk Sendur4,
  35. Murat Toprak26,
  36. Sena Tolu16,
  37. Tiraje Tuncer24
  1. 1Afyonkarahisar Unv Health Sci, Afyon, Turkey
  2. 2Sakarya Unv, Sakarya, Turkey
  3. 3Afyon Hospt, Afyon, Turkey
  4. 4Adnan Menderes Unv, Aydin, Turkey
  5. 5Marmara Unv, İstanbul, Turkey
  6. 6Pamukkale Unv, Denizli, Turkey
  7. 7Balikesir Unv, Balikesir, Turkey
  8. 8Erciyes Unv, Kayseri, Turkey
  9. 9Şanliurfa Hospt, Şanliurfa, Turkey
  10. 10Selçuk Unv, Konya, Turkey
  11. 11Kirikkale Unv, Kirikkale, Turkey
  12. 12Ankara TraiandRes Hospt, Ankara, Turkey
  13. 13Çanakkale 18 Mart Unv, Çanakkale, Turkey
  14. 14Ankara Unv, Ankara, Turkey
  15. 15Dişkapi TraiandRes Hospt, Ankara, Turkey
  16. 16Bezmialem Unv, İstanbul, Turkey
  17. 17Atatürk Unv, Erzurum, Turkey
  18. 18Yildirim Beyazit Unv, Ankara, Turkey
  19. 19Karadeniz Tech Unv, Trabzon, Turkey
  20. 20Recep Tayyip Erdoğan Unv, Rize, Turkey
  21. 21Cumhuriyet Unv, Sivas, Turkey
  22. 22Numune TraiandRes Hospt, Ankara, Turkey
  23. 23Necmettin Erbakan Unv, Konya, Turkey
  24. 24Akdeniz Unv, Antalya, Turkey
  25. 25Kartal Dr. Lütfi Kirdar TraiandRes Hospt, İstanbul, Turkey
  26. 26Yuzuncu Yil Unv, Van, Turkey

Abstract

Background: Psoriatic arthritis (PsA) can lead to significant mental burden affecting several aspects of life in majority of patients. Mental health problems, such as depression and anxiety may result in poor treatment adherence and difficulty in coping with disease burden.

Objectives: The aim of this study is to determine the risk factors associated with clinically significant depression and anxiety in patients with PsA.

Methods: The data from 1128 patients with PsA who met CASPAR classification criteria enrolled by Turkish League Against Rheumatism (TLAR)-Network derived from 25 investigating centers. All of the patients underwent clinical, radiological and also laboratory assessment by using standardized protocol. The associations between psychological variables and clinical parameters were assessed by univariate and multivariate analyses.

Results: Of the 1128 patients with PsA (the mean age 46.9 ±12.2,%64 F), 574 (%50.9) had high risk for depression (HADS-D score ≥7) and 270 (%23.9) for anxiety (HADS-A score ≥10). By univariate analysis, the highest odds ratio (OR) associated with both depression and anxiety were SF36-MCS<50 (OR 6.9, [95%CI:5.3–9]; OR 9, [95%CI:6.5–12.6], respectively. The lowest OR associated with depression belong to PASI total score (OR 1.1, [95%CI:1–1.1]), while the lowest OR associated with anxiety belong to BASMI (OR 1.2, [95%CI:1.1–1.3]). Multivariate logistic regression analysis of potential risk factors for mental health revealed that BASFI (OR 1.9, [95%CI:1.3–2.9], BASDAI (OR 1.6, [95%CI: 1.2–2.3]), BASRI (OR 1.1, [95%CI: 1–1.2]), SF36 MCS<50 (OR 4.7,[95%CI: 3.3–6.8) and unemployed (OR 1.4, [95%CI: 1–1.9]) were factors that influence the risk of depression whereas the BASDAI (OR 1.6, [95%CI: 1–2.4]), SF36 MCS<50 (OR 6, [95%CI: 4–9.2]), BASMI (OR 1.2, [95%CI: 1.1–1.3]) and FIRST5 (OR 3, [95%CI: 2–4.5]) were factors that influence the risk of anxiety.

Conclusion: This large nationwide database indicated that higher disease activity, functional disability, fibromyalgia (FMS), poor health related quality of life as well as structural damage were estimated as the important risk factors for mental disorders in PsA.

Disclosure of Interests: Gamze Kiliç: None declared, Kemal Nas: None declared, Erkan Kilic: None declared, ibrahim tekeoğlu: None declared, Betul Sargin: None declared, Sevtap Acer Kasman: None declared, Hakan Alkan: None declared, Nilay Sahin: None declared, Gizem Cengiz: None declared, Nihan Cuzdan: None declared, Ilknur Albayrak Gezer: None declared, Dilek Keskin: None declared, Cevriye Mülkoğlu: None declared, Hatice Resorlu: None declared, Şebnem Ataman: None declared, Ajda Bal: None declared, Mehmet Tuncay Duruöz Grant/research support from: Abvie, Speakers bureau: Novartis, AMGEN, Abdi İbrahim, İlko, Okan Kucukakkas: None declared, Ozan Volkan Yurdakul: None declared, Meltem Alkan Melikoglu: None declared, Yildiray Aydin: None declared, Figen Ayhan: None declared, Hatice Bodur: None declared, Mustafa Calis: None declared, Erhan Capkin: None declared, Gul Devrimsel: None declared, SAMI HIZMETLI: None declared, Ayhan Kamanli: None declared, Kevser Gok: None declared, Yasar Keskin: None declared, Hilal Kocabas: None declared, Oznur Kutluk: None declared, Nesrin Şen: None declared, Omer Faruk Sendur: None declared, Murat Toprak: None declared, Sena Tolu: None declared, Tiraje Tuncer: None declared:

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