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We read with much interest the paper by Ntari et al 1 and would like to highlight how the high prevalence of fatal arrhythmic events that they found in Tg197 mice might have relevant implications in the clinical setting.
A solid body of data supports the evidence that in patients with chronic inflammatory arthritis (CIA), particularly rheumatoid arthritis (RA), the risk of death is significantly higher than in the general population, and that such a premature mortality is largely related to fatal cardiovascular events.2 In this regard, two population-based studies provided evidence that the prevalence of cardiac arrest (CA) and sudden cardiac death (SCD) is ~2 times higher in patients with RA than in those with no RA.3 4 In addition, in patients with RA, the onset of an acute coronary syndrome is characterised by an increased short-term case …
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Patient consent Not required.
Provenance and peer review Not commissioned; internally peer reviewed.
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