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Is miR200b-5p a new predictor of lymphoma or associated with lymphocytes infiltrate within salivary glands?
  1. Gaetane Nocturne1,
  2. Raphaele Seror2,
  3. Xavier Mariette3,4
  1. 1 Department of Rheumatology, Université Paris-Sud, AP-HP, Hôpitaux Universitaires Paris-Sud, INSERM U1184, Le Kremlin Bicêtre, France
  2. 2 Department of Rheumatology, Hôpitaux universitaires Paris-Sud, Le Kremlin Bicêtre, France
  3. 3 Department of Rheumatology, Hopital Bicetre, Le Kremlin-Bicetre, France
  4. 4 Center for Immunology of Viral Infections and Autoimmune Diseases, INSERM U1184, Paris-Sud University, Le Kremlin Bicêtre, France
  1. Correspondence to Dr Gaetane Nocturne, Department of Rheumatology, Université Paris-Sud, AP-HP, Hôpitaux Universitaires Paris-Sud, INSERM U1184, Le Kremlin Bicêtre, France; gaetane.nocturne{at}aphp.fr

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We read with great interest the paper by Kapsogeorgou et al published recently in The Annals of the Rheumatic Diseases focusing on the link between miR200-5bp and the risk of lymphoma in primary Sjögren syndrome (pSS).1 In this study, the authors assess the level of this miRNA within salivary gland biopsy in three groups of patients with pSS: group 1 is made of patients without lymphoma, group 2 is made of patients at high risk of lymphoma and who developed lymphoma in median 3.67 years after biopsy and the last group 3 is made of patients with lymphoma at the time of biopsy. Interestingly, the authors demonstrate that miR200b-5p is significantly decreased in patients with lymphoma and moreover in patients at high risk of lymphoma. This result strongly suggests that miR200b-5p could be considered as a new biomarker predictor of future occurrence of lymphoma in …

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