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Idiopathic inflammatory myopathies and antisynthetase syndrome: contribution of antisynthetase antibodies to improve current classification criteria
  1. Martin Greco1,
  2. María Jesus García de Yébenes2,
  3. Inmaculada Alarcón3,
  4. Anahy María Brandy-García4,
  5. Íñigo Rúa-Figueroa1,
  6. Estibaliz Loza2,
  7. Loreto Carmona2
  1. 1 Rheumatology Department, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Spain
  2. 2 Instituto de Salud Musculoesquelética, Madrid, Spain
  3. 3 Biochemical Department, Autoimmunity Laboratory, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Spain
  4. 4 Rheumatology Department, Hospital Universitario Central de Asturias, Oviedo, Spain
  1. Correspondence to Dr Martin Greco, Rheumatology Department, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria 35010, Spain; martin-greco{at}

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The presence of muscle weakness and anti-Jo1 anti-aminoacyl transfer RNA synthetase (ARS) autoantibodies are evaluated in the new European League Against Rheumatism/American College of Rheumatology (EULAR/ACR) proposed classification criteria for adult and juvenile idiopathic inflammatory myopathies (IIM), as well as in the Solomon proposed criteria for antisynthetase syndrome (ASSD) diagnosis.1 2 That favours an overlapping in both criteria fulfilment; however, ASSD is not considered among the IIM subgroups classification.

Anti-Jo1 ARS positivity is the highest weighted criterion in the EULAR/ACR criteria. Furthermore, anti-PL7 and anti-PL12 ARS were found to be strongly associated with IIM during the criteria development; however, the low number of observations limited their reliability analysis, and they were not finally included.1 3 Anti-EJ, anti-OJ and other ARS were not considered at all due to the limited availability of detection methods at the start of the criteria development.3 On the other hand, any ARS positivity is considered in Solomon’s criteria.

Thus, according to other authors, we purpose that IIM and ASSD classification criteria …

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  • Handling editor Josef S Smolen

  • Contributors MG: study design, data management, analysis, interpretation, verification, writing. MJGdY: study design, analysis, verification, interpretation. IA: data management, interpretation. AMB-G: data management, interpretation. IR-F: data management, interpretation, writing. EL: interpretation, writing. LC: study design, verification, interpretation, writing.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Ethics approval Ethical approval for this study was obtained from the ethical committee of the Hospital Universitario de Gran Canaria Dr. Negrín (code 2018-222-1).

  • Provenance and peer review Not commissioned; externally peer reviewed.