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T cell receptor β repertoires as novel diagnostic markers for systemic lupus erythematosus and rheumatoid arthritis
  1. Xiao Liu1,2,
  2. Wei Zhang1,2,
  3. Ming Zhao3,
  4. Longfei Fu1,2,
  5. Limin Liu3,
  6. Jinghua Wu1,2,
  7. Shuangyan Luo3,
  8. Longlong Wang1,2,
  9. Zijun Wang3,
  10. Liya Lin1,2,
  11. Yan Liu3,
  12. Shiyu Wang1,2,
  13. Yang Yang3,
  14. Lihua Luo1,2,
  15. Juqing Jiang3,
  16. Xie Wang1,2,
  17. Yixin Tan3,
  18. Tao Li1,2,
  19. Bochen Zhu3,
  20. Yi Zhao1,2,
  21. Xiaofei Gao3,
  22. Ziyun Wan1,2,
  23. Cancan Huang3,
  24. Mingyan Fang1,2,
  25. Qianwen Li3,
  26. Huanhuan Peng1,2,
  27. Xiangping Liao4,
  28. Jinwei Chen5,
  29. Fen Li5,
  30. Guanghui Ling5,
  31. Hongjun Zhao6,
  32. Hui Luo6,
  33. Zhongyuan Xiang7,
  34. Jieyue Liao3,
  35. Yu Liu3,
  36. Heng Yin3,
  37. Hai Long3,
  38. Haijing Wu3,
  39. huanming Yang1,2,8,
  40. Jian Wang1,2,8,
  41. Qianjin Lu3
  1. 1 BGI, Shenzhen, China
  2. 2 China National GeneBank, Shenzhen, China
  3. 3 Department of Dermatology, Hunan Key Laboratory of Medical Epigenomics, The Second Xiangya Hospital of Central South University, Changsha, China
  4. 4 Department of nephropathy and Rheumatology, Chenzhou No.1 People's Hospital, Chenzhou, China
  5. 5 Department of Rheumatology, The Second XiangyaHospital of Central South University, Changsha, China
  6. 6 Department of Rheumatology, Xiangya Hospital of Central South University, Changsha, China
  7. 7 Department of Clinical Laboratory, The Second XiangyaHospital of Central South University, Changsha, China
  8. 8 James D. Watson Institute of Genome Sciences, Hangzhou, China
  1. Correspondence to Dr Qianjin Lu, The Second Xiangya Hospital of Central South University, Changsha, China; qianlu5860{at}csu.edu.cn

Footnotes

  • XL, WZ and MZ contributed equally.

  • Handling editor Prof Josef S Smolen

  • Correction notice This article has been corrected since it published Online First. The fourth author's name has been corrected.

  • Contributors QL, XL, WZ and MZ designed the study, analysed the data and wrote the manuscript. LF, JW, LW, LL, SW, LL, XW, TL, YZ, ZW, MF and HP performed TCR sequencing and data analysis. LL, SL, ZW, YL, YY, JJ, YT, BZ, XG, CH, QL, XL, JC, FL, GL, HZ, HL, ZX JL, YL, HY, HL and HW collected the samples and information of patients and healthy subjects. QL, XL, HY and JW supervised the study.

  • Funding This study was supported by the National Key Research and Development Program of China (2016YFC0903900), the National Natural Science Foundation of China (No. 81430074, No.81522038 and No. 81220108017), the Key research and development plan of Hunan Province (2017SK2042) and the Shenzhen Municipal Government of China (No. JCYJ20170817145536203 and JCYJ20170817145428361).

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Ethics approval The study has been approved by the ethical committee of the Second Xiangya Hospital of Central South University.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement The study data have been made publicly available at pan immune repertoire database (PIRD, https://db.cngb.org/pird/),22 which is located in China National GeneBank (CNGB). The project ID in PIRD are P18081001, P18081101 and P18080801.

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Footnotes

  • XL, WZ and MZ contributed equally.

  • Handling editor Prof Josef S Smolen

  • Correction notice This article has been corrected since it published Online First. The fourth author's name has been corrected.

  • Contributors QL, XL, WZ and MZ designed the study, analysed the data and wrote the manuscript. LF, JW, LW, LL, SW, LL, XW, TL, YZ, ZW, MF and HP performed TCR sequencing and data analysis. LL, SL, ZW, YL, YY, JJ, YT, BZ, XG, CH, QL, XL, JC, FL, GL, HZ, HL, ZX JL, YL, HY, HL and HW collected the samples and information of patients and healthy subjects. QL, XL, HY and JW supervised the study.

  • Funding This study was supported by the National Key Research and Development Program of China (2016YFC0903900), the National Natural Science Foundation of China (No. 81430074, No.81522038 and No. 81220108017), the Key research and development plan of Hunan Province (2017SK2042) and the Shenzhen Municipal Government of China (No. JCYJ20170817145536203 and JCYJ20170817145428361).

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Ethics approval The study has been approved by the ethical committee of the Second Xiangya Hospital of Central South University.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement The study data have been made publicly available at pan immune repertoire database (PIRD, https://db.cngb.org/pird/),22 which is located in China National GeneBank (CNGB). The project ID in PIRD are P18081001, P18081101 and P18080801.

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