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CTB and BR-C contributed equally.
Handling editor Josef S Smolen
Contributors CTB collected the data, analysed data and drafted the manuscript. BR-C collected the data, analysed data and drafted the manuscript. MR has analysed data and contributed to the manuscript writing. TM recruited patients and contributed to the manuscript writing. TD designed the study, analysed data and drafted the manuscript.
Funding This work was funded by the Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (grant no. SNSF PZ00P3-173517) and the ‘Margot und Erich Goldschmidt & Peter René Jacobson-Stiftung’ (both to CTB). MR is supported by a professorship of the Swiss National Science Foundation (PP00P3_173186).
Competing interests None declared.
Patient consent for publication Not required.
Provenance and peer review Not commissioned; externally peer reviewed.
Data sharing statement All data are available as online supplementary data.
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