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Handling editor Josef S Smolen
Contributors Study concept and design: IEL, JR. Acquisition of data: JR, HS, TM, FE. Statistical analysis: FE. Analysis and interpretation of data, drafting manuscript and critical revision of manuscript: all authors.
Funding The Swedish Research Council and King Gustav V:th 80-year Foundation.
Competing interests IEL has received honoraria from Bristol Myers Squibb and MedImmune and is currentlyreceiving a research grant from Bristol Myers Squibb and from Astra Zeneca; and is a scientificadvisor for Bristol Myers Squibb, aTyr and IDERA.
Patient consent for publication Not required.
Ethics approval Our study had the permit for antibody analysis from the Ethics Committee in Stockholm, Sweden.
Provenance and peer review Not commissioned; externally peer reviewed.