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Synovial cellular and molecular signatures stratify clinical response to csDMARD therapy and predict radiographic progression in early rheumatoid arthritis patients

Authors

  • Frances Humby Centre for Experimental Medicine & Rheumatology, William Harvey Research Institute, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, London, UK PubMed articlesGoogle scholar articles
  • Myles Lewis Centre for Experimental Medicine & Rheumatology, William Harvey Research Institute, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, London, UK PubMed articlesGoogle scholar articles
  • Nandhini Ramamoorthi Biomarker Discovery OMNI, Genentech Inc, South San Francisco, California, USA PubMed articlesGoogle scholar articles
  • Jason A Hackney Bioinformatics and Computational Biology, Genentech Inc, South San Francisco, California, USA PubMed articlesGoogle scholar articles
  • Michael R Barnes Centre for Experimental Medicine & Rheumatology, William Harvey Research Institute, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, London, UK Centre for Translational Bioinformatics, William Harvey Research Institute, London, UK PubMed articlesGoogle scholar articles
  • Michele Bombardieri Centre for Experimental Medicine & Rheumatology, William Harvey Research Institute, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, London, UK PubMed articlesGoogle scholar articles
  • A. Francesca Setiadi Biomarker Discovery OMNI, Genentech Inc, South San Francisco, California, USA PubMed articlesGoogle scholar articles
  • Stephen Kelly Centre for Experimental Medicine & Rheumatology, William Harvey Research Institute, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, London, UK PubMed articlesGoogle scholar articles
  • Fabiola Bene Centre for Experimental Medicine & Rheumatology, William Harvey Research Institute, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, London, UK PubMed articlesGoogle scholar articles
  • Maria DiCicco Centre for Experimental Medicine & Rheumatology, William Harvey Research Institute, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, London, UK PubMed articlesGoogle scholar articles
  • Sudeh Riahi Centre for Experimental Medicine & Rheumatology, William Harvey Research Institute, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, London, UK PubMed articlesGoogle scholar articles
  • Vidalba Rocher Centre for Experimental Medicine & Rheumatology, William Harvey Research Institute, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, London, UK PubMed articlesGoogle scholar articles
  • Nora Ng Centre for Experimental Medicine & Rheumatology, William Harvey Research Institute, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, London, UK PubMed articlesGoogle scholar articles
  • Ilias Lazarou Centre for Experimental Medicine & Rheumatology, William Harvey Research Institute, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, London, UK PubMed articlesGoogle scholar articles
  • Rebecca Hands Centre for Experimental Medicine & Rheumatology, William Harvey Research Institute, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, London, UK PubMed articlesGoogle scholar articles
  • Désirée van der Heijde Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands PubMed articlesGoogle scholar articles
  • Robert B M Landewé Amsterdam Rheumatology Center, AMC, Amsterdam, Netherlands Department of Rheumatology, Zuyderland MC, Heerlen, Netherlands PubMed articlesGoogle scholar articles
  • Annette van der Helm-van Mil Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands PubMed articlesGoogle scholar articles
  • Alberto Cauli Universita degli Studi di Cagliari, Cagliari, Italy PubMed articlesGoogle scholar articles
  • Iain McInnes Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK PubMed articlesGoogle scholar articles
  • Christopher Dominic Buckley University of Birmingham, Birmingham, UK PubMed articlesGoogle scholar articles
  • Ernest H Choy Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK PubMed articlesGoogle scholar articles
  • Peter C Taylor Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Kennedy Institute of Rheumatology, Oxford, UK PubMed articlesGoogle scholar articles
  • Michael J Townsend Biomarker Discovery OMNI, Genentech Inc, South San Francisco, California, USA PubMed articlesGoogle scholar articles
  • Costantino Pitzalis Centre for Experimental Medicine & Rheumatology, William Harvey Research Institute, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, London, UK PubMed articlesGoogle scholar articles
  1. Correspondence to Professor Costantino Pitzalis, Centre for Experimental Medicine & Rheumatology, William Harvey Research Institute, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, London, UK; c.pitzalis{at}qmul.ac.uk; Dr Michael J Townsend, Biomarker Discovery OMNI, Genentech Research and Early Development, South San Francisco, USA; townsend.michael{at}gene.com
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Citation

Humby F, Lewis M, Ramamoorthi N, et al
Synovial cellular and molecular signatures stratify clinical response to csDMARD therapy and predict radiographic progression in early rheumatoid arthritis patients

Publication history

  • Received October 6, 2018
  • Revised February 6, 2019
  • Accepted February 14, 2019
  • First published March 16, 2019.
Online issue publication 
May 14, 2019

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