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Comorbidity and long-term outcome in patients with congenital heart block and their siblings exposed to Ro/SSA autoantibodies in utero
  1. Johannes Mofors1,
  2. Håkan Eliasson2,
  3. Aurelie Ambrosi1,
  4. Stina Salomonsson1,
  5. Amanda Skog1,
  6. Michael Fored1,
  7. Anders Ekbom1,
  8. Gunnar Bergman2,
  9. Sven-Erik Sonesson2,
  10. Marie Wahren-Herlenius1
  1. 1 Department of Medicine, Karolinska Institutet, Stockholm, Sweden
  2. 2 Department of Women’s and Children’s Health, Karolinska Universitetssjukhuset, Stockholm, Sweden
  1. Correspondence to Professor Marie Wahren-Herlenius, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden; marie.wahren{at}ki.se

Footnotes

  • Handling editor Josef S Smolen

  • Contributors JM, SS and MWH conceived the study, with support from MF and AE for the study design. HE, GB, SES recruited patients and recorded clinical data. ASA and MWH extracted register data. JM analyzed the data with input from HE, GB, SES and MWH. JM wrote the first version of the manuscript with input from HE, AA, GB, SES and MWH, and all authors participated in the editing until its final version.

  • Funding The study was supported by grants from the Swedish Research Council, the Swedish Rheumatism association, the King Gustaf the V:th 80-year foundation, the Heart-Lung Foundation, the Freemason’s in Stockholm Foundation for Children’s Welfare, the Stockholm County Council, the Karolinska Institute, and the Torsten and Ragnar Söderberg Foundation.

  • Competing interests None declared.

  • Patient consent Not required.

  • Ethics approval The study was approved by the Regional Ethics Committee in Stockholm, and patients or guardians gave written informed consent.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement The ethical permit granted for this study does not allow for sharing to a third party.

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Footnotes

  • Handling editor Josef S Smolen

  • Contributors JM, SS and MWH conceived the study, with support from MF and AE for the study design. HE, GB, SES recruited patients and recorded clinical data. ASA and MWH extracted register data. JM analyzed the data with input from HE, GB, SES and MWH. JM wrote the first version of the manuscript with input from HE, AA, GB, SES and MWH, and all authors participated in the editing until its final version.

  • Funding The study was supported by grants from the Swedish Research Council, the Swedish Rheumatism association, the King Gustaf the V:th 80-year foundation, the Heart-Lung Foundation, the Freemason’s in Stockholm Foundation for Children’s Welfare, the Stockholm County Council, the Karolinska Institute, and the Torsten and Ragnar Söderberg Foundation.

  • Competing interests None declared.

  • Patient consent Not required.

  • Ethics approval The study was approved by the Regional Ethics Committee in Stockholm, and patients or guardians gave written informed consent.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement The ethical permit granted for this study does not allow for sharing to a third party.

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