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B-Lines are a new sonographic hallmark of connective tissue disease–associated interstitial lung diseases (CTD-ILDs). Promising data have shown that B-lines are associated with high-resolution CT (HRCT), pulmonary function test and some clinical variables, expanding the armamentarium for screening of ILDs.1 Krebs von den Lungen-6 (KL-6) antigen is a mucin-like, high molecular weight glycoprotein expressed on the surface membrane of alveolar epithelial cells Ⅱ and bronchiolar epithelial cells, and increases following cellular injury and/or regeneration.2 Its role in patients with CTD-ILDs has been studied extensively, indicating KL-6 as a useful biomarker of lung fibrosis and severity of the disease.3 To the best of our knowledge, the correlation between B-lines and serum KL-6 levels in CTD-ILDs has not been reported until now.
To investigate the relationship between these two markers, 60 Chinese patients with CTD-ILDs were enrolled. Patients with a history of asthma, chronic …
YW and SC contributed equally.
Handling editor Josef S Smolen
Contributors YW, SC, LG, DEF and MM-C designed the study and wrote the manuscript. SC and ZL performed lung ultrasound. GD performed chest high-resolution CT. GZ performed KL-6 analyses. XH performed pulmonary function test. JL and QL collected clinical information. All authors have read and contributed to the final text and also approved the submitted version.
Competing interests Luna Gargani received speaker honoraria from GE Healthcare and Glaxo-Smith-Kline.
Patient consent Obtained.
Ethics approval Approved by the Shantou Central Hospital Ethics Committee.
Provenance and peer review Not commissioned; externally peer reviewed.
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