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Hypomethylation of STAT1 and HLA-DRB1 is associated with type-I interferon-dependent HLA-DRB1 expression in lupus CD8+ T cells

Footnotes

  • SM and P-ST contributed equally.

  • Handling editor Josef S Smolen

  • Contributors All authors listed contributed and fulfil authorship criteria as follows: Substantial contributions to the conception or design of the work or the acquisition, analysis or interpretation of data for the work; Drafting the work or revising it critically for important intellectual content; Final approval of the version to be published and Agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

  • Funding This work was supported by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health grant number R01AI097134.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Ethics approval This study was approved by the Institutional Review Board of the University of Michigan, and each study participant signed an approved written consent prior to participating in this study.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement Raw and processed DNA methylation data from patients and controls have been deposited in Gene Expression Omnibus (GEO accession number GSE123003)

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Footnotes

  • SM and P-ST contributed equally.

  • Handling editor Josef S Smolen

  • Contributors All authors listed contributed and fulfil authorship criteria as follows: Substantial contributions to the conception or design of the work or the acquisition, analysis or interpretation of data for the work; Drafting the work or revising it critically for important intellectual content; Final approval of the version to be published and Agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

  • Funding This work was supported by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health grant number R01AI097134.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Ethics approval This study was approved by the Institutional Review Board of the University of Michigan, and each study participant signed an approved written consent prior to participating in this study.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement Raw and processed DNA methylation data from patients and controls have been deposited in Gene Expression Omnibus (GEO accession number GSE123003)

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