You are here

Article Text

Article menu

Download PDFPDF

Correspondence
M-CSF and GM-CSF monocyte-derived macrophages in systemic sclerosis: the two sides of the same coin?
Free
  1. Alain Lescoat1,2,
  2. Patrick Jégo1,2,
  3. Valérie Lecureur1
  1. 1 Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail)-UMR_S 1085, F-35000 Rennes, France
  2. 2 Médecine Interne, CHU Rennes, Rennes, France
  1. Correspondence to Dr Alain Lescoat, Internal Medicine, CHU South Hospital, Rennes 35203, France; alain.lescoat{at}chu-rennes.fr

https://doi.org/10.1136/annrheumdis-2018-213112

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    We read with interest the article by Moreno-Moral et al 1 exploring the contribution of monocyte-derived macrophages (MDMs) in mediating genetic susceptibility to systemic sclerosis (SSc). By conducting RNA sequencing and genome-wide genotyping in a model of MDMs differentiated by macrophage colony-stimulating factor (M-CSF), this article provides new insights in the activation/polarisation states of blood MDMs in SSc.

    In this work, the blood MDMs from 57 patients with SSc present a mixed activation signature state (figure 1 in ref.1): on the one hand, the down-regulation of interferon gamma response is in favour …

    View Full Text

    Linked Articles