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Handling editor Josef S Smolen
Contributors Original concept provided by SK. Data collection, analysis and manuscript formulation by NP. All other authors contributed to the manuscript editorial process.
Competing interests None declared.
Patient consent Not required.
Ethics approval Research Ethics Committee.
Provenance and peer review Not commissioned; externally peer reviewed.
Data sharing statement All data created are available with the permission from Costantino Pitzalis as part of the MRC PEAC study REC reference: 05/Q0703/198 and IRAS Project ID: 60271.