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Response to: ‘Bisphosphonates reduce the risk of knee replacement: we need more analyses!’ by Li et al
  1. Tuhina Neogi,
  2. Shanshan Li,
  3. Christine Peloquin,
  4. Devyani Misra,
  5. Yuqing Zhang
  1. Clinical Epidemiology Unit, Boston University School of Medicine, Boston, Massachusetts, USA
  1. Correspondence to Dr Tuhina Neogi, Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA 02118, USA; tneogi{at}

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We thank Dr Li and colleagues1 for their interest in our paper. As outlined in our paper,2 we used data from a large general practitioner electronic health records database for our study. These data are collected and recorded as part of routine clinical care with diagnostic codes. As such, factors such as willingness to undergo and access to knee replacement (KR), knee pain severity, disability, quality of life and others are not available in this database, and we were thus unable to examine these as potential confounders. We were, however, able to account for socioeconomic status (Townsend Deprivation Index), and performed sensitivity analyses demonstrating that substantial residual confounding is unlikely. The assessment of bisphosphonate exposure was based on prescription data, and alendronate was the most common bisphosphonate prescribed (84%), as described in the paper.2 The potential mechanisms by which bisphosphonates may confer the noted effects were beyond the scope of this paper. Nonetheless, it is not clear that bisphosphonate initiation would alter one’s willingness to undergo KR or access to KR such that a protective effect would be noted in our study. We included both total and unicompartmental primary knee arthroplasty since either surgery would indicate substantially symptomatic knee osteoarthritis, but did not include revision surgery since the reasons for that procedure are not for severe/end-stage osteoarthritis; this is the same approach used by the other studies we had cited on this matter. As per standard time-to-event analyses, subjects were censored at the first KR, among the other censoring factors outlined in the paper.



  • Handling editor Josef S Smolen

  • Funding This research received no specific grant from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Commissioned; internally peer reviewed.

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