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Interaction between B-cell activation factor and methotrexate impacts immunogenicity of seasonal influenza vaccination in patients with rheumatoid arthritis

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Footnotes

  • YJL and SB contributed equally.

  • Handling editor Josef S Smolen

  • Contributors JKP, YJL, SB, KLW, YC, EBL and XM contributed to the acquisition, analysis or interpretation of data and critical revision of the manuscript for important intellectual content. XM had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. JKP, EBL and XM were responsible for the study concept and design and drafting of the manuscript.

  • Funding This study was sponsored by GC Pharma (formally known as Green Cross Corporation, Yongin-si, South Korea).

  • Competing interests EBL has acted as a consultant to Pfizer and received research grants from GC Pharma and Hanmi Pharm.

  • Patient consent Obtained.

  • Ethics approval The study was approved by the Institutional Review Board of the Seoul National University Hospital (IRB 1608-158-787) and was conducted in accordance with the principles of the Declaration of Helsinki and Good Clinical Practice guidelines. The study was registered with http://www.clinicaltrials.gov, protocol number: NCT02897011. The protocol allows to use the stored sera for additional testing.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data statement The corresponding author had full access to all the data in the study and final responsibility for the decision to submit for publication.