Immunological and clinical effects of low-dose interleukin-2 across 11 autoimmune diseases in a single, open clinical trial

Michelle Rosenzwajg; Roberta Lorenzon; Patrice Cacoub; Hang Phuong Pham; Fabien Pitoiset; Karim El Soufi; Claire RIbet; Claude Bernard; Selim Aractingi; Beatrice Banneville; Laurent Beaugerie; Francis Berenbaum; Julien Champey; Olivier Chazouilleres; Christophe Corpechot; Bruno Fautrel; Arsène Mekinian; Elodie Regnier; David Saadoun; Joe-Elie Salem; Jérémie Sellam; Philippe Seksik; Anne Daguenel-Nguyen; Valérie Doppler; Jéremie Mariau; Eric Vicaut; David Klatzmann

doi:10.1136/annrheumdis-2018-214229

Article info

Connective tissue diseases

Immunological and clinical effects of low-dose interleukin-2 across 11 autoimmune diseases in a single, open clinical trial

Authors

Michelle Rosenzwajg Inflammation-Immunopathology-Biotherapy Department (i2B), AP-HP, Pitié-Salpêtrière Hospital, Paris, France Immunology-Immunopathology- Immunotherapy (i3), Sorbonne Université, INSERM, Paris, France PubMed articles Google scholar articles
Roberta Lorenzon Inflammation-Immunopathology-Biotherapy Department (i2B), AP-HP, Pitié-Salpêtrière Hospital, Paris, France Immunology-Immunopathology- Immunotherapy (i3), Sorbonne Université, INSERM, Paris, France PubMed articles Google scholar articles
Patrice Cacoub Inflammation-Immunopathology-Biotherapy Department (i2B), AP-HP, Pitié-Salpêtrière Hospital, Paris, France Immunology-Immunopathology- Immunotherapy (i3), Sorbonne Université, INSERM, Paris, France Department of Internal Medicine and Clinical Immunology, AP-HP, Pitié-Salpêtrière Hospital, Paris, France PubMed articles Google scholar articles
Hang Phuong Pham ILTOO Pharma, Paris, France PubMed articles Google scholar articles
Fabien Pitoiset Inflammation-Immunopathology-Biotherapy Department (i2B), AP-HP, Pitié-Salpêtrière Hospital, Paris, France Immunology-Immunopathology- Immunotherapy (i3), Sorbonne Université, INSERM, Paris, France PubMed articles Google scholar articles
Karim El Soufi Inflammation-Immunopathology-Biotherapy Department (i2B), AP-HP, Pitié-Salpêtrière Hospital, Paris, France Immunology-Immunopathology- Immunotherapy (i3), Sorbonne Université, INSERM, Paris, France PubMed articles Google scholar articles
Claire RIbet Inflammation-Immunopathology-Biotherapy Department (i2B), AP-HP, Pitié-Salpêtrière Hospital, Paris, France PubMed articles Google scholar articles
Claude Bernard Inflammation-Immunopathology-Biotherapy Department (i2B), AP-HP, Pitié-Salpêtrière Hospital, Paris, France Immunology-Immunopathology- Immunotherapy (i3), Sorbonne Université, INSERM, Paris, France PubMed articles Google scholar articles
Selim Aractingi Department of Dermatology, AP-HP Cochin Hospital, Paris, France PubMed articles Google scholar articles
Beatrice Banneville Department of Rheumatology, AP-HP Pitié-Salpêtrière Hospital, Paris, France PubMed articles Google scholar articles
Laurent Beaugerie Department of Gastroenterology, AP-HP Saint Antoine Hospital, Paris, France PubMed articles Google scholar articles
Francis Berenbaum Department of Rheumatology, AP-HP Saint-Antoine Hospital, Paris, France PubMed articles Google scholar articles
Julien Champey Department of Rheumatology, AP-HP Saint-Antoine Hospital, Paris, France PubMed articles Google scholar articles
Olivier Chazouilleres Department of Hepatology, AP-HP Saint-Antoine Hospital, Paris, France PubMed articles Google scholar articles
Christophe Corpechot Department of Hepatology, AP-HP Saint-Antoine Hospital, Paris, France PubMed articles Google scholar articles
Bruno Fautrel Department of Rheumatology, AP-HP Pitié-Salpêtrière Hospital, Paris, France PubMed articles Google scholar articles
Arsène Mekinian Department of Internal Medicine, AP-HP, Saint-Antoine Hospital, Paris, France PubMed articles Google scholar articles
Elodie Regnier Department of Dermatology, AP-HP Cochin Hospital, Paris, France PubMed articles Google scholar articles
David Saadoun Inflammation-Immunopathology-Biotherapy Department (i2B), AP-HP, Pitié-Salpêtrière Hospital, Paris, France Immunology-Immunopathology- Immunotherapy (i3), Sorbonne Université, INSERM, Paris, France Department of Internal Medicine and Clinical Immunology, AP-HP, Pitié-Salpêtrière Hospital, Paris, France PubMed articles Google scholar articles
Joe-Elie Salem Department of Pharmacology and CIC-1421, AP-HP Pitié-Salpêtrière Hospital, Paris, France PubMed articles Google scholar articles
Jérémie Sellam Department of Rheumatology, AP-HP Saint-Antoine Hospital, Paris, France PubMed articles Google scholar articles
Philippe Seksik Department of Gastroenterology, AP-HP Saint Antoine Hospital, Paris, France PubMed articles Google scholar articles
Anne Daguenel-Nguyen Department of Pharmacy, AP-HP Saint-Antoine Hospital, Paris, France PubMed articles Google scholar articles
Valérie Doppler ILTOO Pharma, Paris, France PubMed articles Google scholar articles
Jéremie Mariau ILTOO Pharma, Paris, France PubMed articles Google scholar articles
Eric Vicaut Unité de Recherche Clinique and Université Paris, AP-HP Saint Louis/Lariboisière Hospitals, Paris, France PubMed articles Google scholar articles
David Klatzmann Inflammation-Immunopathology-Biotherapy Department (i2B), AP-HP, Pitié-Salpêtrière Hospital, Paris, France Immunology-Immunopathology- Immunotherapy (i3), Sorbonne Université, INSERM, Paris, France PubMed articles Google scholar articles

Correspondence to Professor David Klatzmann, Clinical Investigation Center for Biotherapies and Inflammation-Immunopathology-Biotherapy department (i2B), Hôpital Pitié-Salpêtrière, Paris F-75013, France; david.klatzmann{at}sorbonne-universite.fr

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Citation

Rosenzwajg M, Lorenzon R, Cacoub P, et al

Immunological and clinical effects of low-dose interleukin-2 across 11 autoimmune diseases in a single, open clinical trial

Annals of the Rheumatic Diseases 2019;78:209-217.

Publication history

Received August 2, 2018
Revised October 29, 2018
Accepted November 1, 2018
First published November 24, 2018.

Online issue publication

June 29, 2023

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