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Coffee consumption and gout: a Mendelian randomisation study
  1. Young Ho Lee
  1. Anam Hospital, Korea University, Seoul 02841, Republic of Korea
  1. Correspondence to Professor Young Ho Lee, Anam Hospital, Korea University, Seoul 02841, Republic of Korea; lyhcgh{at}

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I have read with great interest the article by Larsson and Carlström1 regarding coffee consumption and gout. This Mendelian randomisation (MR) analysis demonstrates that coffee consumption may lower the risk of gout. When a randomised controlled trial is lacking because of an unethical or infeasible issue, MR studies may help address the causal relationship. However, it has some methodological issues. The primary concern relates to whether the MR study has adequate statistical power to detect an association. An increase in the variance in the trait of interest …

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