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Footnotes
Handling editor Josef S Smolen
Contributors SK, HH, JJ and AM coordinated the laboratory examinations and data analysis. SK, PL, AK, WK, SS and GR coordinated the clinical examinations and reviewed data analysis as well as revised the manuscript. SK, AM, PL and GR designed, coordinated the study and reviewed the data. SK, GR, PL and AM wrote the manuscript.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Patient consent for publication Not required.
Ethics approval Institutional review board at the University of Luebeck (Az 16-199).
Provenance and peer review Not commissioned; externally peer reviewed.