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Crystal arthropathies
Genome-wide association study revealed novel loci which aggravate asymptomatic hyperuricaemia into gout

Authors

  • Yusuke Kawamura Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan Department of General Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan PubMed articlesGoogle scholar articles
  • Hirofumi Nakaoka Division of Human Genetics, Department of Integrated Genetics, National Institute of Genetics, Mishima, Shizuoka, Japan PubMed articlesGoogle scholar articles
  • Akiyoshi Nakayama Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan Medical Squadron, Air Base Group, Western Aircraft Control and Warning Wing, Japan Air Self-Defense Force, Kasuga, Fukuoka, Japan PubMed articlesGoogle scholar articles
  • Yukinori Okada Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Osaka, Japan PubMed articlesGoogle scholar articles
  • Ken Yamamoto Department of Medical Biochemistry, Kurume University School of Medicine, Kurume, Fukuoka, Japan PubMed articlesGoogle scholar articles
  • Toshihide Higashino Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan PubMed articlesGoogle scholar articles
  • Masayuki Sakiyama Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan Department of Defense Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan PubMed articlesGoogle scholar articles
  • Toru Shimizu Midorigaoka Hospital, Takatsuki, Osaka, Japan Kyoto Industrial Health Association, Kyoto, Japan PubMed articlesGoogle scholar articles
  • Hiroshi Ooyama Ryougoku East Gate Clinic, Tokyo, Japan PubMed articlesGoogle scholar articles
  • Keiko Ooyama Ryougoku East Gate Clinic, Tokyo, Japan PubMed articlesGoogle scholar articles
  • Mitsuo Nagase Nagase Clinic, Tokyo, Japan PubMed articlesGoogle scholar articles
  • Yuji Hidaka Akasaka Central Clinic, Tokyo, Japan PubMed articlesGoogle scholar articles
  • Yuko Shirahama Department of Medical Biochemistry, Kurume University School of Medicine, Kurume, Fukuoka, Japan PubMed articlesGoogle scholar articles
  • Kazuyoshi Hosomichi Department of Bioinformatics and Genomics, Graduate School of Advanced Preventive Medical Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan PubMed articlesGoogle scholar articles
  • Yuichiro Nishida Department of Preventive Medicine, Faculty of Medicine, Saga University, Saga, Japan PubMed articlesGoogle scholar articles
  • Ippei Shimoshikiryo Department of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan PubMed articlesGoogle scholar articles
  • Asahi Hishida Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan PubMed articlesGoogle scholar articles
  • Sakurako Katsuura-Kamano Department of Preventive Medicine, Institute of Health Biosciences, the University of Tokushima Graduate School, Tokushima, Japan PubMed articlesGoogle scholar articles
  • Seiko Shimizu Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan PubMed articlesGoogle scholar articles
  • Makoto Kawaguchi Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan Department of Urology, National Defense Medical College, Tokorozawa, Saitama, Japan PubMed articlesGoogle scholar articles
  • Hirokazu Uemura Department of Preventive Medicine, Institute of Health Biosciences, the University of Tokushima Graduate School, Tokushima, Japan PubMed articlesGoogle scholar articles
  • Rie Ibusuki Department of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan PubMed articlesGoogle scholar articles
  • Megumi Hara Department of Preventive Medicine, Faculty of Medicine, Saga University, Saga, Japan PubMed articlesGoogle scholar articles
  • Mariko Naito Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan Department of Oral Epidemiology, Hiroshima University Graduate School of Biomedical & Health Sciences, Hiroshima, Japan PubMed articlesGoogle scholar articles
  • Mikiya Takao Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan Department of Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan PubMed articlesGoogle scholar articles
  • Mayuko Nakajima Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan PubMed articlesGoogle scholar articles
  • Satoko Iwasawa Department of Preventive Medicine and Public Health, National Defense Medical College, Tokorozawa, Saitama, Japan PubMed articlesGoogle scholar articles
  • Hiroshi Nakashima Department of Preventive Medicine and Public Health, National Defense Medical College, Tokorozawa, Saitama, Japan PubMed articlesGoogle scholar articles
  • Keizo Ohnaka Department of Geriatric Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan PubMed articlesGoogle scholar articles
  • Takahiro Nakamura Laboratory for Mathematics, National Defense Medical College, Tokorozawa, Saitama, Japan PubMed articlesGoogle scholar articles
  • Blanka Stiburkova Institute of Rheumatology, Prague, Czech Republic Department of Pediatrics and Adolescent Medicine, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic PubMed articlesGoogle scholar articles
  • Tony R Merriman Department of Biochemisty, University of Otago, Dunedin, New Zealand PubMed articlesGoogle scholar articles
  • Masahiro Nakatochi Data Science Division, Data Coordinating Center, Department of Advanced Medicine, Nagoya University Hospital, Nagoya, Aichi, Japan PubMed articlesGoogle scholar articles
  • Sahoko Ichihara Department of Environmental and Preventive Medicine, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan PubMed articlesGoogle scholar articles
  • Mitsuhiro Yokota Department of Genome Science, School of Dentistry, Aichi Gakuin University, Nagoya, Aichi, Japan PubMed articlesGoogle scholar articles
  • Tappei Takada Department of Pharmacy, the University of Tokyo Hospital, Tokyo, Japan PubMed articlesGoogle scholar articles
  • Tatsuya Saitoh Laboratory of Bioresponse Regulation, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan Division of Inflammation Biology, Institute for Enzyme Research, Tokushima University, Tokushima, Japan PubMed articlesGoogle scholar articles
  • Yoichiro Kamatani Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan PubMed articlesGoogle scholar articles
  • Atsushi Takahashi Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan Department of Genomic Medicine, Research Institute, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan PubMed articlesGoogle scholar articles
  • Kokichi Arisawa Department of Preventive Medicine, Institute of Health Biosciences, the University of Tokushima Graduate School, Tokushima, Japan PubMed articlesGoogle scholar articles
  • Toshiro Takezaki Department of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan PubMed articlesGoogle scholar articles
  • Keitaro Tanaka Department of Preventive Medicine, Faculty of Medicine, Saga University, Saga, Japan PubMed articlesGoogle scholar articles
  • Kenji Wakai Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan PubMed articlesGoogle scholar articles
  • Michiaki Kubo RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan PubMed articlesGoogle scholar articles
  • Tatsuo Hosoya Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Minato-ku, Tokyo, Japan Department of Pathophysiology and Therapy in Chronic Kidney Disease, Jikei University School of Medicine, Minato-ku, Tokyo, Japan PubMed articlesGoogle scholar articles
  • Kimiyoshi Ichida Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Minato-ku, Tokyo, Japan Department of Pathophysiology, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan PubMed articlesGoogle scholar articles
  • Ituro Inoue Division of Human Genetics, Department of Integrated Genetics, National Institute of Genetics, Mishima, Shizuoka, Japan PubMed articlesGoogle scholar articles
  • Nariyoshi Shinomiya Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan PubMed articlesGoogle scholar articles
  • Hirotaka Matsuo Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Hirotaka Matsuo, Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Saitama 359-8513, Japan; hmatsuo{at}ndmc.ac.jp
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Citation

Kawamura Y, Nakaoka H, Nakayama A, et al
Genome-wide association study revealed novel loci which aggravate asymptomatic hyperuricaemia into gout
Annals of the Rheumatic Diseases 2019;78:1430-1437.

Publication history

  • Received April 9, 2019
  • Revised May 20, 2019
  • Accepted May 21, 2019
  • First published July 8, 2019.
Online issue publication 
April 19, 2023

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© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.