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PPARγ preservation via promoter demethylation alleviates osteoarthritis in mice
  1. Xiaobo Zhu1,
  2. Fang Chen2,
  3. Ke Lu1,
  4. Ai Wei2,
  5. Qing Jiang1,3,
  6. Wangsen Cao2
  1. 1 State Key Laboratory of Pharmaceutical Biotechnology, Department of Sports Medicine and Adult Reconstructive Surgery, The Affiliated Drum Tower Hospital of Nanjing University School of Medicine, Nanjing, China
  2. 2 Jiangsu Key Laboratory of Molecular Medicine, Nanjing University School of Medicine, Nanjing, China
  3. 3 Model Animal Research Center, Nanjing University, Nanjing, China
  1. Correspondence to Dr Wangsen Cao, Nanjing University School of Medicine, Nanjing, China; wangsencao{at}nju.edu.cn; Dr Qing Jiang, The Affiliated Drum Tower Hospital of Nanjing University School of Medicine, Nanjing, China; qingj{at}nju.edu.cn

Footnotes

  • Handling editor Josef S Smolen

  • Contributors XZ conducted the most assays and acquired and analysed data. FC, KL and AW participated in some experiments. QJ and WC conceived the project. WC designed the study, arranged/analysed the results and wrote the manuscript. All authors have approved the final version of the manuscript.

  • Competing interests None declared.

  • Patient consent for publication Not reqiured.

  • Ethics approval The animal use and the experimental protocols were reviewed and approved by the Animal Care Committee of Nanjing University in accordance with the Institutional Animal Care and Use Committee guidelines.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement All data relevant to the study are included in the article or uploaded as supplementary information.

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Footnotes

  • Handling editor Josef S Smolen

  • Contributors XZ conducted the most assays and acquired and analysed data. FC, KL and AW participated in some experiments. QJ and WC conceived the project. WC designed the study, arranged/analysed the results and wrote the manuscript. All authors have approved the final version of the manuscript.

  • Competing interests None declared.

  • Patient consent for publication Not reqiured.

  • Ethics approval The animal use and the experimental protocols were reviewed and approved by the Animal Care Committee of Nanjing University in accordance with the Institutional Animal Care and Use Committee guidelines.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement All data relevant to the study are included in the article or uploaded as supplementary information.

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