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Secretory form of rheumatoid arthritis–associated autoantibodies in serum are mainly of the IgM isotype, suggesting a continuous reactivation of autoantibody responses at mucosal surfaces

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Footnotes

  • Handling editor Josef S Smolen

  • Contributors MAMvD set up the study design and performed the experiments, as well as the analysis, interpretation of the data, drafting the article and approval of the final manuscript. DvdW and REMT contributed to the interpretation of the data, revising the manuscript and approval of the final manuscript. LAT contributed to study design, interpretation of the data, revising the manuscript and approval of the final manuscript.

  • Funding This work was supported by the Dutch Arthritis Foundation (14-2-402) and the IMI JU–funded project BeTheCure (115142-2). DvdW is supported by a ZON-MW Veni grant, REMT by a ZON-MW Vici grant and LAT is supported by a ZON-MW Vidi grant (91712334).

  • Competing interests REMT and LAT are listed as inventors in a patent application regarding the detection of anti-CarP antibodies for RA.

  • Patient consent Not required.

  • Ethics approval Ethical committee of the LUMC.

  • Provenance and peer review Not commissioned; externally peer reviewed.