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  • FRI0574 Radiofrequency echographic multi spectrometry (REMS) for the non-ionising diagnosis of osteoporosis at femoral neck: results of a multicenter clinical study comparing rems and dxa

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FRIDAY, 15 JUNE 2018
Diagnostics and imaging procedures
FRI0574 Radiofrequency echographic multi spectrometry (REMS) for the non-ionising diagnosis of osteoporosis at femoral neck: results of a multicenter clinical study comparing rems and dxa
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  1. L. Cavalli1,
  2. G. Arioli§,
  3. G. Bianchi2,§,
  4. C. Caffarelli3,§,
  5. M. Matucci Cerinic4,§,
  6. L. Cianferotti5,§,
  7. F. Conversano1,§,
  8. M. Di Paola6,
  9. D. Gatti6,§,
  10. G. Girasole7,§,
  11. A. Giusti8,§,
  12. S. Gonnelli3,§,
  13. M. Manfredini4,§,
  14. M. Muratore2,§,
  15. R. Nuti9,§,
  16. P. Pisani4,§,
  17. E. Quarta6,§,
  18. M. Rossini9,§,
  19. O. Viapiana7,§,
  20. M.L. Brandi7,1
  1. § =Equal contributors listed in alphabetical order
  2. 1Department of Surgery and Translational Medicine, University of Florence, Metabolic Bone Diseases Unit, University Hospital of Florence, Florence, Italy, Firenze
  3. 2Department of Neurosciences and Rehabilitation, “Carlo Poma” Hospital, ASST, Mantova
  4. 3SC Rheumatology, ASL 3 Genovese, Genova
  5. 4Department of Medicine, Surgery and Neurosciences, University of Siena, Siena
  6. 5Department of Experimental and Clinical Medicine, University of Florence and SOD Rheumatology AOUC, Florence, Italy, Firenze
  7. 6Institute of Clinical Physiology, National Research Council, Lecce
  8. 7Rheumatology Unit, Department of Medicine, University of Verona, Verona
  9. 8“Carlo Poma” Hospital, ASST, Mantova
  10. 9O.U. of Rheumatology, “Galateo” Hospital, San Cesario di Lecce, ASL-LE, Lecce, Italy

Abstract

Background Radiofrequency Echographic Multi Spectrometry (REMS) is an innovative densitometric technique able to automatically provide BMD values, which it has been shown to highly correlate with BMD obtained by DXA.1

Objectives To evaluate the accuracy of REMS measurements in postmenopausal women’s femoral neck health assessment versus DXA results in a multicenter clinical study.

Methods In seven Italian referral centres for osteoporosis management, 1659 postmenopausal women (51–70 years old) were enrolled. Both DXA and REMS examinations were performed on each patient at femoral neck, in the strictest adherence to the corresponding guidelines. After excluding the scans affecting by errors, the REMS diagnostic accuracy was evaluated by assessing sensibility and specificity in the discrimination between “osteoporotic” and “healthy” patients; the degree of correlation between DXA-BMD and REMS-BMD was quantified through Pearson’s correlation coefficient (r) evaluation. In addition, the agreement between DXA-BMD and REMS-BMD was measured calculating the root mean square error (RMSE).

Results A strong correlation (r=0.94, p<0.001) was detected between BMD obtained by DXA and REMS – estimated BMD at femoral neck, with a low residual error (RMSE=0.034 g/cm2). In addition to this, REMS resulted to have a high capability to discriminate osteoporotic from healthy patients (sensibility=94.4%, specificity=95.6%).

Conclusions Thanks to its high capability to identify osteoporotic patients, and the strong correlation with DXA parameters, REMS has been shown to be an accurate non-ionising approach to detect osteoporosis at femoral neck.

Reference [1] Casciaro S, et al. UMB2016;42:1337–56.

Disclosure of Interest None declared

https://doi.org/10.1136/annrheumdis-2018-eular.7476

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