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OP0020 Validation of new systemic lupus erythematosus classification criteria
  1. M. Aringer1,
  2. K.H. Costenbader2,
  3. R. Brinks3,
  4. D. Boumpas4,
  5. D. Daikh5,
  6. D. Jayne6,
  7. D. Kamen7,
  8. M. Mosca8,
  9. R. Ramsey-Goldman9,
  10. J.S. Smolen10,
  11. D. Wofsy5,
  12. B. Diamond11,
  13. S. Jacobsen12,
  14. W.J. McCune13,
  15. G. Ruiz-Irastorza14,
  16. M. Schneider15,
  17. M.B. Urowitz16,
  18. G. Bertsias17,
  19. B. Hoyer18,
  20. N. Leuchten1,
  21. C. Tani8,
  22. S. Tedeschi2,
  23. Z. Touma16,
  24. B. Anic19,
  25. F. Assan20,
  26. T.M. Chan21,
  27. A.E. Clarke22,
  28. M.K. Crow23,
  29. L. Czírják24,
  30. A. Doria25,
  31. W. Graninger26,
  32. S. Hasni27,
  33. P. Izmirly28,
  34. M. Jung22,
  35. B. Kiss24,
  36. X. Mariette20,
  37. I. Padjen19,
  38. J.M. Pego-Reigosa29,
  39. J. Romero-Díaz30,
  40. I. Rúa-Figueroa31,
  41. R. Seror20,
  42. G. Stummvoll10,
  43. Y. Tanaka32,
  44. M. Tektonidou4,
  45. C. Vasconcelos33,
  46. E. Vital34,
  47. D.J. Wallace35,
  48. S. Yavuz36,
  49. R.P. Naden37,
  50. T. Dörner38,
  51. S.R. Johnson16
  1. 1TU Dresden, Dresden, Germany
  2. 2Harvard Medical School, Boston, MA, USA
  3. 3Hiller Center for Research in Rheumatology, Düsseldorf, Germany
  4. 4University of Athens, Athens, Greece
  5. 5UCSF, San Francisco, CA, USA
  6. 6University of Cambridge, Cambridge, UK
  7. 7MUSC, Charleston, SC, USA
  8. 8University of Pisa, Pisa, Italy
  9. 9Northwestern University, Chicago, IL, USA
  10. 10Medical University of Vienna, Vienna, Austria
  11. 11Feinstein Institute, Manhasset, NY, USA
  12. 12Rigshospitalet, Copenhagen, Denmark
  13. 13University of Michigan, Ann Arbor, MI, USA
  14. 14UPV/EHU, Bizkaia, Spain
  15. 15Universität Düsseldorf, Düsseldorf, Germany
  16. 16University of Toronto, Toronto, Canada
  17. 17University of Crete, Heraklion, Greece
  18. 18UKSH, Kiel, Germany
  19. 19University Hospital, Zagreb, Croatia
  20. 20Université Paris Sud, Paris, France
  21. 21University of Hong Kong, Hong Kong, China
  22. 22University of Calgary, Calgary, Canada
  23. 23HSS, New York, NY, USA
  24. 24University of Pécs, Pécs, Hungary
  25. 25University of Padova, Padova, Italy
  26. 26Medical University of Graz, Graz, Austria
  27. 27NIAMS, NIH, Bethesda, MD
  28. 28NYU, New York, NY, USA
  29. 29University of Vigo, Vigo, Spain
  30. 30INCMNSZ, Mexico City, Mexico
  31. 31Hospital Dr Negrin, Las Palmas, Spain
  32. 32University of Occupational and Environmental Health, Kitakyushu, Japan
  33. 33University of Porto, Porto, Portugal
  34. 34University of Leeds, Leeds, UK
  35. 35Cedars-Sinai, Los Angeles, CA, USA
  36. 36Istanbul Bilim University, Istanbul, Turkey
  37. 37New Zealand Ministry of Health, Auckland, New Zealand
  38. 38Charité University, Berlin, Germany

Abstract

Background This 4 phase project1 jointly supported by EULAR and ACR has led to draft criteria.2

Objectives To simplify and validate the new criteria in a large international cohort.

Methods 23 expert centres each contributed up to 100 patients with SLE and with non-SLE diagnoses. Diagnoses were verified by 3 independent reviewers for 1,193 SLE and 1059 non-SLE patients. 500 randomly selected SLE and non-SLE patients formed the derivation cohort and the remainder the validation cohort.

Results The criteria were fine-tuned and simplified, using ANA of ≥1:80 as entry criterion and a classification threshold of 10.

Sensitivity was close to the SLICC 2012 criteria, specificity maintained at the level of the ACR 1997 criteria. This performance was independently confirmed in the validation cohort.

Conclusions The new criteria developed with EULAR/ACR support achieved sensitivity close to the SLICC criteria, while maintaining the specificity of the ACR criteria.

References [1] Aringer, et al. Ann Rheum Dis2017;76(S2):4.

[2] Tedeschi, et al. Ann Rheum Dis2017;76(S2):50.

Disclosure of Interest None declared

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